Kim Se Eun, Lee Eunseok, Jang Kwangsik, Shim Kyung Mi, Kang Seong Soo
College of Veterinary Medicine, BK21 Plus Project Team and Biomaterial R&BD Center, Chonnam National University, Gwangju, Republic of Korea.
College of Veterinary Medicine, BK21 Plus Project Team and Biomaterial R&BD Center, Chonnam National University, Gwangju, Republic of Korea
In Vivo. 2018 Nov-Dec;32(6):1419-1426. doi: 10.21873/invivo.11394.
BACKGROUND/AIM: The purpose of this study was to develop hybrid bone blocks using porcine-derived collagen and low crystalline porcine-derived hydroxyapatite to overcome the disadvantages of commonly used bone grafts in dentistry.
Collagen was added to hydroxyapatite particles to increase the spatial integration of particulate bone grafts. Physicochemical examination and in vivo tests were performed to analyze scaffold's characteristics and evaluate bone regeneration.
Porcine hybrid bone block had an irregular and interconnecting macroporous structure that was adequate for bone regeneration and bone ingrowth, and showed a good space-occupying ability to become well positioned. In addition, it showed higher angiogenesis and biodegradability than Bio-Oss Collagen®, a commercialized bone graft used in dental clinics.
Our results suggest that improved collagen hybrid bone block can be generated when porcine cancellous bone particles and collagen were reasonably mixed. This hybrid bone block was easy in handling had flexibility, good biodegradability and provided bone regeneration.
背景/目的：本研究的目的是使用猪源胶原蛋白和低结晶度猪源羟基磷灰石开发混合骨块，以克服牙科常用骨移植材料的缺点。
将胶原蛋白添加到羟基磷灰石颗粒中，以增加颗粒状骨移植材料的空间整合性。进行了物理化学检查和体内试验，以分析支架的特性并评估骨再生情况。
猪混合骨块具有不规则且相互连通的大孔结构，适合骨再生和骨长入，并且显示出良好的占位能力，能够很好地定位。此外，与牙科诊所使用的商业化骨移植材料Bio-Oss Collagen®相比，它具有更高的血管生成能力和生物降解性。
我们的结果表明，当猪松质骨颗粒和胶原蛋白合理混合时，可以制备出改良的胶原蛋白混合骨块。这种混合骨块易于操作，具有柔韧性、良好的生物降解性并能促进骨再生。
