Minkov I P, Podgornaia T G
Kardiologiia. 1990 Jul;30(7):80-2.
The study was undertaken to examine 80 children with congenital heart and vessel malformations, their parents (50 married couples), and 100 families with healthy children. The antigen typing of the HLA system was accomplished by using the Terasaki microlymphocytotoxic test. A statistically significant correlation was found between B35 antigens and septal malformations, vascular diseases, and congenital cardiomyopathies. The unfavorable obstetric history was shown to play a role in the occurrence of developmental malformations. The data of an analysis of HLA antigens in the parents of the children with congenital malformations suggest that a marked HLA antigen compatibility of married couples is one of the cause of pregnancy complications and developmental malformations in their offspring.
该研究对80名患有先天性心脏和血管畸形的儿童、他们的父母（50对已婚夫妇）以及100个有健康孩子的家庭进行了检查。采用特拉萨基微量淋巴细胞毒试验完成HLA系统的抗原分型。发现B35抗原与间隔缺损、血管疾病和先天性心肌病之间存在统计学上的显著相关性。不良产科史被证明在发育畸形的发生中起作用。对患有先天性畸形儿童的父母进行HLA抗原分析的数据表明，已婚夫妇之间显著的HLA抗原相容性是其后代妊娠并发症和发育畸形的原因之一。
