先天性弓形虫病中的人类白细胞抗原分型
HLA typing in congenital toxoplasmosis.
作者信息
Meenken C, Rothova A, de Waal L P, van der Horst A R, Mesman B J, Kijlstra A
机构信息
Department of Ophthalmo-Immunology, The Netherlands Ophthalmic Research Institute, Amsterdam.
出版信息
Br J Ophthalmol. 1995 May;79(5):494-7. doi: 10.1136/bjo.79.5.494.
HLA-A, HLA-B, HLA-C, and HLA-D typing was performed in 47 mothers of patients suffering from ocular toxoplasmosis to investigate whether an immunogenetic predisposition exists for developing congenital toxoplasmosis in their offspring. No significant association between any HLA antigen was observed in the mothers of patients with ocular toxoplasmosis, although a total absence of the HLA-B51 antigen was found in this group. HLA-A, HLA-B, and HLA-C typing was also performed in their children (52 patients with ocular toxoplasmosis), to investigate a possible relation between the severity of ocular toxoplasmosis and an eventual immunogenetic factor. In the patients with ocular toxoplasmosis an increased frequency of the HLA-Bw62 antigen was observed in correlation with severe ocular involvement.
对47名患有眼弓形虫病患者的母亲进行了HLA - A、HLA - B、HLA - C和HLA - D分型，以调查其后代发生先天性弓形虫病是否存在免疫遗传易感性。在患有眼弓形虫病患者的母亲中，未观察到任何HLA抗原之间存在显著关联，尽管在该组中发现完全缺乏HLA - B51抗原。还对她们的孩子（52名患有眼弓形虫病的患者）进行了HLA - A、HLA - B和HLA - C分型，以研究眼弓形虫病的严重程度与最终免疫遗传因素之间的可能关系。在患有眼弓形虫病的患者中，观察到HLA - Bw62抗原频率增加与严重眼部受累相关。
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