趋化细胞因子受体 5 基因多态性：与 2 型糖尿病微血管并发症的相关性。
Chemotactic cytokine receptor 5 gene polymorphism: relevance to microvascular complications in type 2 diabetes.
机构信息
Laboratory for DNA Analysis and Molecular Diagnostics, Department of Nephrology, Medical University of Lublin, Lublin, Poland.
出版信息
Cytokine. 2012 May;58(2):213-7. doi: 10.1016/j.cyto.2012.01.007. Epub 2012 Feb 9.
We investigated the involvement of chemotactic cytokine receptor 5 (CCR5) gene polymorphism in microvascular complications of T2DM. All subjects were genotyped with the 59029 SNP in the CCR5 gene. The genotype/allele frequencies did not differ between T2DM patients and controls. Genotype distribution was compared in patients with and without complications (nephropathy, retinopathy and neuropathy). The frequency of A allele was significantly higher in patients with complications (OR for A allele 3.07, 95% CI 2.49-3.77). The A allele carriage was associated with diabetic nephropathy (OR 6.17, 95% CI 3.28-11.6). An association was observed between 59029 polymorphism and age at T2DM onset. The A allele was more frequent in early onset than in late onset patients. For AA homozygotes OR was 2.38 (1.19-4.76) and 2.26 (1.12-4.58) in complicated and uncomplicated subgroups, respectively. These results suggest that CCR5 gene polymorphism is associated with diabetic nephropathy in T2DM.
我们研究了趋化因子受体 5 (CCR5) 基因多态性在 2 型糖尿病微血管并发症中的作用。所有受试者均采用 CCR5 基因 59029 SNP 进行基因分型。2 型糖尿病患者和对照组之间的基因型/等位基因频率没有差异。比较了有并发症（肾病、视网膜病变和神经病变）和无并发症患者的基因型分布。在有并发症的患者中，A 等位基因的频率显著升高（A 等位基因的 OR 为 3.07，95%CI 为 2.49-3.77）。A 等位基因携带与糖尿病肾病相关（OR 为 6.17，95%CI 为 3.28-11.6）。还观察到 59029 多态性与 2 型糖尿病发病年龄之间存在关联。A 等位基因在早发患者中比晚发患者更常见。对于 AA 纯合子，在有并发症和无并发症亚组中，OR 分别为 2.38（1.19-4.76）和 2.26（1.12-4.58）。这些结果表明，CCR5 基因多态性与 2 型糖尿病的糖尿病肾病有关。
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