Facultad de Ciencias Químicas, Instituto Multidisciplinario de Biología Vegetal (IMBIV-CONICET) , Universidad Nacional de Córdoba , Casilla de Correo 495 , 5000 Córdoba , Argentina.
BioLab, Instituto Universitario de Bio-Orgánica "Antonio González" (IUBO-AG), Centro de Investigaciones Biomédicas de Canarias (CIBICAN) , Universidad de La Laguna , C/Astrofísico Francisco Sánchez 2 , 38206 La Laguna , Spain.
J Nat Prod. 2019 May 24;82(5):1338-1344. doi: 10.1021/acs.jnatprod.9b00117. Epub 2019 May 9.
Four new withanolides (2-5), together with 4β,7β,20-trihydroxy-1-oxowitha-2,5,24-trienolide (1), were isolated from the aerial parts of Eriolarynx iochromoides. The antiproliferative activity of all compounds purified from E. iochromoides together with four withaphysalins and four physangulidines isolated previously from three Deprea species were evaluated against human solid tumor cell lines. Four withanolides showed antiproliferative activity comparable in potency to cisplatin. Selectivity toward cancer cells and interaction with P-glycoprotein of the active withanolides were evaluated.
从异叶白前的地上部分中分离得到了四个新的 20-羟基羽扇豆烷型三萜（2-5），以及 4β,7β,20-三羟基-1-氧代-2,5,24-三烯羽扇豆烷内酯（1）。从三种 Deprea 属植物中分离得到的四个 withaphysalins 和四个 physangulidines 与从 Eriolarynx iochromoides 中分离得到的所有化合物一起评估了它们对人实体瘤细胞系的抗增殖活性。四个 20-羟基羽扇豆烷型三萜表现出与顺铂相当的抗增殖活性。评估了活性 withanolides 对癌细胞的选择性和与 P-糖蛋白的相互作用。
