Laraway D C, Lakshmiah R, Lowe D, Roe B, Rogers S N
Liverpool Dental School, Pembroke Place, University of Liverpool, Liverpool L69 3BX, UK.
Br J Oral Maxillofac Surg. 2012 Dec;50(8):715-20. doi: 10.1016/j.bjoms.2012.01.010. Epub 2012 Feb 11.
There is a growing elderly population presenting with, and surviving, oral cancer. Making decisions about treatment is complex, and is influenced in part by prognosis and expected outcomes for health-related quality of life (HRQoL). We used the University of Washington Head and Neck Quality of Life scale (UWQoL) to compare HRQoL in patients by age group at a time closest to one year after primary surgery. Survival was analysed using data from the Office for National Statistics. A consecutive series of 1091 patients treated curatively for oral squamous cell carcinoma (SCC) at the regional maxillofacial unit at Aintree University Hospital between 1992 and 2009 were included in the main analysis. UWQoL data for 638 patients were available from about one year after treatment. Older patients (65 years or over) reported better physical and emotional function notably in regard to appearance, speech, saliva (75 years and over), pain, shoulder, mood, and anxiety than younger patients with head and neck cancer treated by operation. In conclusion, older patients seem to cope and adjust well to treatment and this is reflected in their HRQoL scores, which are higher in many domains than those of younger patients with head and neck cancer.
患口腔癌并存活下来的老年人口正在增加。做出治疗决策很复杂，部分受到预后以及健康相关生活质量（HRQoL）预期结果的影响。我们使用华盛顿大学头颈部生活质量量表（UWQoL），在初次手术后最接近一年的时间，按年龄组比较患者的HRQoL。使用国家统计局的数据对生存率进行分析。主要分析纳入了1992年至2009年间在艾恩特里大学医院区域颌面外科接受口腔鳞状细胞癌（SCC）根治性治疗的连续1091例患者。638例患者在治疗后约一年的UWQoL数据可用。老年患者（65岁及以上）在外观、言语、唾液（75岁及以上）、疼痛、肩部、情绪和焦虑方面的身体和情感功能明显优于接受手术治疗的年轻头颈癌患者。总之，老年患者似乎能很好地应对和适应治疗，这在他们的HRQoL评分中得到体现，在许多领域，老年患者的评分高于年轻头颈癌患者。
