School of Health Sciences, The University of Liverpool, UK; Ministry of Health, Radiology Department, Saudi Arabia.
Neurosci Lett. 2012 Mar 23;512(2):94-8. doi: 10.1016/j.neulet.2012.01.064. Epub 2012 Feb 6.
The purpose of this study was to investigate the brain circuitry involved in the processing of both positive and negative emotions in normal healthy subjects.
we have recruited 15 healthy volunteers (9 males and 6 females, age range 30-60). In this block-design fMRI study, we compared the blood oxygen level dependant (BOLD) signal change as response to pleasant and unpleasant IAPS pictures, each compared to a neutral condition.
Pleasant pictures versus neutral condition contrast demonstrated significant activation (p(FDRcorrected) <0.05) in bilateral pre-frontal cortex (PFC), anterior and posterior cingulate gyri and temporal lobe. Unpleasant pictures relative to neutral condition exhibit significant activation (p(FDRcorrected) <0.05) in amygdala, hippocampus, parahippocampal gyri, temporal lobe, visual cortex, fusiform gyri, PFC and anterior cingulate gyrus.
Amygdala is mainly involved in the processing of negative emotions. Although an overlap in regions involved in the processing of pleasant and unpleasant IAPS pictures exists, the neural network for each is unique.
本研究旨在探讨正常健康受试者处理正性和负性情绪的大脑回路。
我们招募了 15 名健康志愿者（9 名男性，6 名女性，年龄 30-60 岁）。在这项基于块的 fMRI 研究中，我们比较了血氧水平依赖（BOLD）信号变化作为对愉快和不愉快 IAPS 图片的反应，每种图片都与中性条件进行比较。
与中性条件相比，愉快图片的对比显示双侧前额叶皮层（PFC）、前后扣带回和颞叶有显著激活（p（FDR 校正）<0.05）。与中性条件相比，不愉快图片显示杏仁核、海马体、海马旁回、颞叶、视觉皮层、梭状回、PFC 和前扣带回有显著激活（p（FDR 校正）<0.05）。
杏仁核主要参与负性情绪的处理。尽管参与处理愉快和不愉快 IAPS 图片的区域存在重叠，但每个区域的神经网络都是独特的。
