Hofer Alex, Siedentopf Christian M, Ischebeck Anja, Rettenbacher Maria A, Verius Michael, Felber Stephan, Fleischhacker W Wolfgang
Medical University Innsbruck, Department of Biological Psychiatry, Anichstrasse 35, A-6020 Innsbruck, Austria.
Neuroimage. 2006 Aug 15;32(2):854-62. doi: 10.1016/j.neuroimage.2006.03.053. Epub 2006 May 19.
Whether men activate different brain regions during various emotions compared to women or whether gender differences exist in transient emotional states has been the subject of only few studies. We used event-related functional magnetic resonance imaging (fMRI) to investigate gender differences during the perception of positive or negative emotions. The experiment comprised two emotional conditions (pleasant/unpleasant visual stimuli) during which fMRI data were acquired. Altogether, 38 healthy volunteers (19 males, 19 females) were investigated. When subtracting the activation values of men from those of women, suprathreshold positive signal changes were detected in the right posterior cingulate, the left putamen and the left cerebellum during positive mood induction, and in bilateral superior temporal gyri and cerebellar vermis during negative mood induction. The subtraction of activation values of women from those of men yielded no significant differences. Our findings suggest gender-related neural responses to emotional stimuli and could contribute to the understanding of mechanisms underlying gender-related vulnerability of the prevalence and severity of neuropsychiatric disorders.
与女性相比，男性在各种情绪状态下是否会激活不同的脑区，或者在短暂的情绪状态中是否存在性别差异，这些问题仅在少数研究中有所涉及。我们使用事件相关功能磁共振成像（fMRI）来研究在感知积极或消极情绪过程中的性别差异。该实验包括两种情绪条件（愉悦/不愉快的视觉刺激），在此期间采集fMRI数据。总共对38名健康志愿者（19名男性，19名女性）进行了研究。当从女性的激活值中减去男性的激活值时，在积极情绪诱导期间，右侧后扣带回、左侧壳核和左侧小脑检测到超阈值的正信号变化，在消极情绪诱导期间，双侧颞上回和小脑蚓部检测到超阈值的正信号变化。从男性的激活值中减去女性的激活值则未发现显著差异。我们的研究结果表明了与性别相关的对情绪刺激的神经反应，可能有助于理解神经精神疾病患病率和严重程度方面与性别相关的易感性背后的机制。
