• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

表观遗传学在银屑病中的作用：甲基化的胞嘧啶-鸟嘌呤位点可区分皮损与非皮损皮肤以及正常皮肤。

A role for epigenetics in psoriasis: methylated Cytosine-Guanine sites differentiate lesional from nonlesional skin and from normal skin.

机构信息

Department of Dermatology, University of Michigan, Ann Arbor, Michigan 48109, USA.

出版信息

J Invest Dermatol. 2012 Mar;132(3 Pt 1):506-8. doi: 10.1038/jid.2011.364.

DOI:10.1038/jid.2011.364
PMID:22327261
Abstract

DNA methylation is one of several epigenetic mechanisms that can lead to stable and heritable changes in gene expression without changing the underlying DNA sequence. In this issue, Roberson et al. demonstrate that lesional skin in psoriasis is accompanied by changes in DNA methylation, which revert back to baseline with treatment, indicating that DNA methylation in psoriasis is dynamic.

摘要

DNA 甲基化是几种表观遗传机制之一，它可以导致基因表达的稳定和可遗传的变化，而不会改变潜在的 DNA 序列。在本期杂志中，Roberson 等人证明，银屑病皮损伴随着 DNA 甲基化的变化，这些变化在治疗后恢复到基线水平，表明银屑病中的 DNA 甲基化是动态的。

相似文献

1
A role for epigenetics in psoriasis: methylated Cytosine-Guanine sites differentiate lesional from nonlesional skin and from normal skin.表观遗传学在银屑病中的作用：甲基化的胞嘧啶-鸟嘌呤位点可区分皮损与非皮损皮肤以及正常皮肤。
J Invest Dermatol. 2012 Mar;132(3 Pt 1):506-8. doi: 10.1038/jid.2011.364.
2
A subset of methylated CpG sites differentiate psoriatic from normal skin.一组甲基化 CpG 位点可将银屑病皮肤与正常皮肤区分开来。
J Invest Dermatol. 2012 Mar;132(3 Pt 1):583-92. doi: 10.1038/jid.2011.348. Epub 2011 Nov 10.
3
Whole-genome DNA methylation in skin lesions from patients with psoriasis vulgaris.寻常型银屑病患者皮损的全基因组 DNA 甲基化。
J Autoimmun. 2013 Mar;41:17-24. doi: 10.1016/j.jaut.2013.01.001. Epub 2013 Jan 29.
4
Genome-Wide DNA Methylation Profiling Identifies Differential Methylation in Uninvolved Psoriatic Epidermis.全基因组 DNA 甲基化分析鉴定未受累银屑病表皮中的差异甲基化。
J Invest Dermatol. 2018 May;138(5):1088-1093. doi: 10.1016/j.jid.2017.11.036. Epub 2017 Dec 13.
5
Epigenome-Wide Association Analysis Identified Nine Skin DNA Methylation Loci for Psoriasis.全基因组关联分析鉴定出九个银屑病皮肤 DNA 甲基化位点。
J Invest Dermatol. 2016 Apr;136(4):779-787. doi: 10.1016/j.jid.2015.12.029. Epub 2015 Dec 29.
6
Dominant lesional T cell receptor rearrangements persist in relapsing psoriasis but are absent from nonlesional skin: evidence for a stable antigen-specific pathogenic T cell response in psoriasis vulgaris.优势性病变T细胞受体重排在复发性银屑病中持续存在，但在非病变皮肤中不存在：寻常型银屑病中稳定的抗原特异性致病性T细胞反应的证据。
J Invest Dermatol. 2001 Nov;117(5):1296-301. doi: 10.1046/j.0022-202x.2001.01494.x.
7
Genomic DNA methylation in HLA-Cw*0602 carriers and non-carriers of psoriasis.银屑病 HLA-Cw*0602 携带者和非携带者的基因组 DNA 甲基化。
J Dermatol Sci. 2020 Jul;99(1):23-29. doi: 10.1016/j.jdermsci.2020.05.006. Epub 2020 May 31.
8
Abnormal DNA methylation in skin lesions and PBMCs of patients with psoriasis vulgaris.寻常型银屑病患者皮肤损伤和外周血单核细胞中的异常DNA甲基化
J Dermatol Sci. 2010 Oct;60(1):40-2. doi: 10.1016/j.jdermsci.2010.07.011. Epub 2010 Aug 3.
9
The methylation pattern of p16INK4a gene promoter in psoriatic epidermis and its clinical significance.银屑病表皮中p16INK4a基因启动子的甲基化模式及其临床意义。
Br J Dermatol. 2008 May;158(5):987-93. doi: 10.1111/j.1365-2133.2008.08505.x. Epub 2008 Mar 28.
10
Detection of epidermal cellular DNA content and its clinical significance in psoriasis vulgaris.寻常型银屑病表皮细胞DNA含量检测及其临床意义
J Dermatol. 1995 Jun;22(6):419-23.

引用本文的文献

1
DNA hypomethylation leads to cGAS-induced autoinflammation in the epidermis.DNA 低甲基化导致表皮中 cGAS 诱导的自身炎症。
EMBO J. 2021 Nov 15;40(22):e108234. doi: 10.15252/embj.2021108234. Epub 2021 Sep 29.
2
Pathogenesis of psoriasis in the "omic" era. Part II. Genetic, genomic and epigenetic changes in psoriasis.“组学”时代银屑病的发病机制。第二部分。银屑病的遗传、基因组和表观遗传变化。
Postepy Dermatol Alergol. 2020 Jun;37(3):283-298. doi: 10.5114/ada.2020.96243. Epub 2020 Jul 14.
3
Upregulation of the miRNA-155, miRNA-210, and miRNA-20b in psoriasis patients and their relation to IL-17.
银屑病患者中 miRNA-155、miRNA-210 和 miRNA-20b 的上调及其与 IL-17 的关系。
Int J Immunopathol Pharmacol. 2020 Jan-Dec;34:2058738420933742. doi: 10.1177/2058738420933742.
4
Integrated Analysis of Methylome and Transcriptome Changes Reveals the Underlying Regulatory Signatures Driving Curly Wool Transformation in Chinese Zhongwei Goats.甲基化组和转录组变化的综合分析揭示了驱动中国中卫山羊卷曲羊毛转变的潜在调控特征。
Front Genet. 2020 Jan 8;10:1263. doi: 10.3389/fgene.2019.01263. eCollection 2019.
5
Th17 Cells and the IL-23/IL-17 Axis in the Pathogenesis of Periodontitis and Immune-Mediated Inflammatory Diseases.辅助性 T 细胞 17 及其相关细胞因子在牙周炎和免疫介导性炎症疾病发病机制中的作用。
Int J Mol Sci. 2019 Jul 10;20(14):3394. doi: 10.3390/ijms20143394.
6
Psoriasis Pathogenesis and Treatment.银屑病发病机制与治疗。
Int J Mol Sci. 2019 Mar 23;20(6):1475. doi: 10.3390/ijms20061475.
7
Whole-genome bisulfite sequencing of goat skins identifies signatures associated with hair cycling.对山羊皮进行全基因组亚硫酸氢盐测序，鉴定与毛发周期相关的特征。
BMC Genomics. 2018 Aug 28;19(1):638. doi: 10.1186/s12864-018-5002-5.
8
DNA methylation-based subclassification of psoriasis in the Chinese Han population.基于 DNA 甲基化的中国汉族人群银屑病亚分类。
Front Med. 2018 Dec;12(6):717-725. doi: 10.1007/s11684-017-0588-6. Epub 2018 Apr 5.
9
Chronic skin inflammation accelerates macrophage cholesterol crystal formation and atherosclerosis.慢性皮肤炎症加速巨噬细胞胆固醇结晶形成和动脉粥样硬化。
JCI Insight. 2018 Jan 11;3(1). doi: 10.1172/jci.insight.97179.
10
Increased expression of interleukin-17 pathway genes in nonlesional skin of moderate-to-severe psoriasis vulgaris.寻常型中重度银屑病非皮损皮肤中白细胞介素-17通路基因表达增加。
Br J Dermatol. 2016 Jan;174(1):136-45. doi: 10.1111/bjd.14034. Epub 2015 Nov 11.