含双齿 N-杂环卡宾配体的银配合物的增强细胞毒性。
Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands.
机构信息
School of Chemistry, University of Leeds, UK.
出版信息
Dalton Trans. 2012 Apr 7;41(13):3720-5. doi: 10.1039/c2dt12399a. Epub 2012 Feb 13.
PMID:22327273
Abstract
A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands.
摘要
已制备了一系列带有双（N-杂环卡宾）配体的阳离子银配合物，它们对腺癌 MCF7 和 DLD1 的细胞毒性与顺铂相当。二齿配体的细胞毒性强于单齿配体和大环配体。
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