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抗癌银-N-杂环卡宾配合物的聚合物包封

Polymer encapsulation of anticancer silver-N-heterocyclic carbene complexes.

作者信息

Mohamed H A, Khuphe M, Boardman S J, Shepherd S, Phillips R M, Thornton P D, Willans C E

机构信息

School of Chemistry, University of Leeds Woodhouse Lane Leeds LS2 9JT UK

Department of Pharmacy, University of Huddersfield Queensgate Huddersfield HD1 3DH UK.

出版信息

RSC Adv. 2018 Mar 15;8(19):10474-10477. doi: 10.1039/c8ra00450a. eCollection 2018 Mar 13.

DOI:10.1039/c8ra00450a
PMID:35540495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9078921/
Abstract

Amphiphilic block copolymers have been developed for the encapsulation of organometallic drugs. silver-N-heterocyclic carbene complexes have shown significant promise as anticancer and antibacterial compounds, and have been studied as the payload in these carriers. Simple modification of the N-heterocyclic carbene ligand structure enables solubility properties and interaction with the polymer to be tuned.

摘要

两亲性嵌段共聚物已被开发用于包封有机金属药物。银-N-杂环卡宾配合物作为抗癌和抗菌化合物已显示出巨大的潜力，并已被研究作为这些载体中的有效载荷。对N-杂环卡宾配体结构进行简单修饰可以调节其溶解性以及与聚合物的相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4884/9078921/3b59328bbe93/c8ra00450a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4884/9078921/37a63f1145c6/c8ra00450a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4884/9078921/4e66f96fbda3/c8ra00450a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4884/9078921/23d78c84a78b/c8ra00450a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4884/9078921/2a42a837eaa0/c8ra00450a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4884/9078921/6da6ace9adf2/c8ra00450a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4884/9078921/3b59328bbe93/c8ra00450a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4884/9078921/37a63f1145c6/c8ra00450a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4884/9078921/4e66f96fbda3/c8ra00450a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4884/9078921/23d78c84a78b/c8ra00450a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4884/9078921/2a42a837eaa0/c8ra00450a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4884/9078921/6da6ace9adf2/c8ra00450a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4884/9078921/3b59328bbe93/c8ra00450a-f6.jpg

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