性别和亚型对酒精中毒患者血小板单胺氧化酶的影响。
The effect of gender and subtype on platelet MAO in alcoholism.
作者信息
Yates W R, Wilcox J, Knudson R, Myers C, Kelly M W
机构信息
Department of Psychiatry, College of Medicine, University of Iowa, Iowa City 52242.
出版信息
J Stud Alcohol. 1990 Sep;51(5):463-7. doi: 10.15288/jsa.1990.51.463.
Decreased platelet MAO activity has been identified in male alcoholics with suggestions that this is primarily true of Type 2 alcoholics as defined by criteria from the Stockholm Adoption Study. Little information has been available regarding platelet MAO activity in female alcoholics. This study evaluated a group of 71 alcoholics receiving inpatient treatment, including 16 female alcoholics, for platelet MAO activity compared to controls. Female alcoholic's platelet MAO was significantly lower than controls and not different from activity levels in male alcoholics. Among male alcoholics, both Type 1 and Type 2 subgroups were lower than controls and Type 2 levels did not differ from Type 1 levels. Thus, we were unable to replicate a gender and subgroup low platelet MAO specificity among alcoholics, but did find significant differences between alcoholics and controls.
已发现男性酗酒者血小板单胺氧化酶（MAO）活性降低，有迹象表明，按照斯德哥尔摩收养研究的标准定义，这主要适用于2型酗酒者。关于女性酗酒者血小板MAO活性的信息很少。本研究评估了一组71名接受住院治疗的酗酒者，其中包括16名女性酗酒者，以比较其与对照组的血小板MAO活性。女性酗酒者的血小板MAO显著低于对照组，且与男性酗酒者的活性水平无差异。在男性酗酒者中，1型和2型亚组均低于对照组，且2型水平与1型水平无差异。因此，我们无法在酗酒者中复制性别和亚组低血小板MAO特异性，但确实发现了酗酒者与对照组之间的显著差异。
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