Otsuki T, Agatsuma Y, Jokura H, Sakurada S, Kisara K, Yoshimoto T
Department of Neurosurgery, Tohoku University School of Medicine, Sendai, Japan.
J Neurosci Methods. 1990 Aug;33(2-3):229-31. doi: 10.1016/0165-0270(90)90026-c.
The analgesic effects of various agents were evaluated in knee joint monoarthritic rats where arthritis was induced by monosodium urate (MSU) crystals injected into the knee joint cavities. The weight supported by each hind limb was measured quantitatively using pressure transducers, which revealed dose-dependent recovery produced by various analgesics including morphine but no changes in value by sedatives such as chlorpromazine. Relative potency obtained from the value of ED50 of each analgesic agent was congruent with that in clinical use. The MSU test may be quite suitable for quantitative and objective evaluation of the analgesic effects of various agents, particularly for spontaneous and tonic pain.
在通过向膝关节腔注射尿酸单钠（MSU）晶体诱导关节炎的膝关节单关节炎大鼠中，评估了各种药物的镇痛效果。使用压力传感器定量测量每个后肢支撑的重量，结果显示包括吗啡在内的各种镇痛药产生了剂量依赖性恢复，而氯丙嗪等镇静剂的值没有变化。从每种镇痛药的ED50值获得的相对效价与临床使用中的效价一致。MSU试验可能非常适合对各种药物的镇痛效果进行定量和客观评估，特别是对于自发痛和持续性疼痛。
