Okuda Kazuhisa, Nakahama Hiroshi, Miyakawa Hiroyoshi, Shima Keisetsu
Division of Neurophysiology, Institute of Brain Diseases, Tohoku University School of Medicine, I-I Seiryo-Cho, Sendai 980 Japan.
Pain. 1984 Mar;18(3):287-297. doi: 10.1016/0304-3959(84)90823-6.
An attempt has been made to determine whether cats rendered arthritic by the injection of monosodium urate (MSU) crystals (rod-shaped 40-130 micrometers length) into one knee joint capsule can be used as animal model of tonic (chronic) pain. A limp and a decrease in body weight supported by the injected hind leg's paw occurred approximately 1 h after the MSU (20 mg) injection, reached a maximum at 2-3 h, and lasted for more than 6 h before a gradual return to pre-injection levels. They were diminished by systemic administration and local (the dorsal part of the nucleus raphe dorsalis) application of morphine, this effect being blocked by naloxone. This suggests that the limping and the paw pressure decrease are the reflexion of pain. It is suggested that the animal model of the MSU-induced arthritis is useful for the study of tonic pain.
已经进行了一项尝试，以确定通过向一个膝关节囊中注射尿酸单钠（MSU）晶体（棒状，长度为40 - 130微米）而导致关节炎的猫是否可以用作强直性（慢性）疼痛的动物模型。在注射MSU（20毫克）后约1小时，注射后腿的爪子支撑出现跛行和体重下降，在2 - 3小时达到最大值，并持续超过6小时，然后才逐渐恢复到注射前水平。全身给药和局部（中缝背核背侧部分）应用吗啡可减轻这些症状，这种作用被纳洛酮阻断。这表明跛行和爪子压力降低是疼痛的反映。有人认为，MSU诱导的关节炎动物模型对于研究强直性疼痛是有用的。
