Good R A, Lorenz E, Engelman R, Day N K
Department of Pediatrics, All Children's Hospital, University of South Florida, St. Petersburg 33701.
Med Oncol Tumor Pharmacother. 1990;7(2-3):183-92. doi: 10.1007/BF02988547.
Chronic energy intake restriction (CEIR) inhibits lymphoproliferative disease, autoimmune-based renal disease and mammary adenocarcinoma in mice of numerous short-lived strains (MRL/lpr, C3H/Bi, C3H/Ou). Doubling and tripling of life span and health span and inhibition of development of diseases associated with aging could be attributed to restriction of calories but not to restriction of dietary fat in the absence of calorie restriction. In mice of both long- and short-lived strains, CEIR dramatically prevents the waning of immunologic vigor that commonly occurs with aging, delays thymic involution, impairs formation of circulating immune complexes, prevents the renal injury that accompanies autoimmune disease, and significantly forestalls development of genetically determined lymphoproliferative or neoplastic disease. Evidence suggests that CEIR may exert these beneficial influences in part through regulation of cellular proliferation. Trace elements, particularly zinc, as well as vitamins may play important roles in maintaining immunocompetence and also appear to be of significance in the dietary prevention of certain experimental cancers.
长期能量摄入限制（CEIR）可抑制多种短命品系（MRL/lpr、C3H/Bi、C3H/Ou）小鼠的淋巴细胞增生性疾病、自身免疫性肾病和乳腺腺癌。在不限制热量的情况下，寿命和健康寿命延长两倍和三倍以及与衰老相关疾病发展的抑制可归因于热量限制而非膳食脂肪限制。在长寿和短命品系的小鼠中，CEIR都能显著防止通常随衰老出现的免疫活力衰退，延缓胸腺退化，损害循环免疫复合物的形成，预防自身免疫性疾病伴随的肾损伤，并显著延缓遗传性淋巴细胞增生性或肿瘤性疾病的发展。有证据表明，CEIR可能部分通过调节细胞增殖发挥这些有益作用。微量元素，尤其是锌，以及维生素在维持免疫能力方面可能起重要作用，并且在某些实验性癌症的膳食预防中似乎也具有重要意义。
