Shao R P, Dao M L, Day N K, Good R A
University of South Florida, All Children's Hospital, St. Petersburg 33701.
Proc Soc Exp Biol Med. 1990 Apr;193(4):313-7. doi: 10.3181/00379727-193-43041.
Chronic energy intake restriction (CEIR) in virgin female mice is one of the most effective ways of reducing significantly mammary adenocarcinoma in C3H/Bi mice, a strain which develops mammary adenocarcinoma associated with the murine mammary tumor virus spontaneously and at high incidence. In this study, the influence of chronic energy intake restriction imposed on fully mature (4- to 5-month-old), breeding female C3H/Bi mice was addressed, and the influence of energy intake where energy was derived largely from fat versus diets in which energy was derived largely from carbohydrates on tumor development and survival rate was investigated. The results show that chronic energy intake restriction can be delayed until full maturation and successful reproduction and still reduce significantly the incidence of mammary tumor development in this relatively short-lived strain of mice. Our findings demonstrate that the overriding dietary factor controlling mammary tumor development in these experiments in C3H/Bi mice was the level of energy intake, regardless of the primary source of energy (fat or carbohydrates).
对未生育的雌性小鼠进行长期能量摄入限制（CEIR）是显著降低C3H/Bi小鼠乳腺腺癌的最有效方法之一。C3H/Bi小鼠是一种会自发且高发与鼠乳腺肿瘤病毒相关的乳腺腺癌的品系。在本研究中，探讨了对完全成熟（4至5月龄）的C3H/Bi繁殖雌性小鼠进行长期能量摄入限制的影响，并研究了能量主要来源于脂肪的饮食与能量主要来源于碳水化合物的饮食对肿瘤发展和存活率的影响。结果表明，长期能量摄入限制可以推迟到完全成熟和成功繁殖之后，并且在这种寿命相对较短的小鼠品系中仍能显著降低乳腺肿瘤的发生几率。我们的研究结果表明，在这些针对C3H/Bi小鼠的实验中，控制乳腺肿瘤发展的首要饮食因素是能量摄入水平，而不论能量的主要来源是脂肪还是碳水化合物。
