Cook M G, McNamara P
Cancer Res. 1980 Apr;40(4):1329-31.
This study investigates the effect of variations in dietary vitamin E on the incidence of dimethylhydrazine-induced colonic tumors in mice. Two groups of 65 LACA mice were given 28 weekly s.c. injections of dimethylhydrazine. The only difference in the management of the two groups was the dietary content of vitamin E; one group received 10 mg/kg, and the other group received 600 mg/kg. Of these two groups, 42 and 51 mice, respectively, survived, and there were significantly more adenomas, more adenomas with pleomorphic cytology, and more invasive carcinomas in the group receiving a low vitamin E supplement to their diet. It is suggested that vitamin E may have some part to play in the multifactorial effect of diet on colorectal carcinogenesis.
本研究调查了饮食中维生素E的变化对二甲基肼诱导的小鼠结肠肿瘤发生率的影响。两组各65只LACA小鼠每周皮下注射28次二甲基肼。两组管理上的唯一差异在于饮食中维生素E的含量；一组接受10毫克/千克，另一组接受600毫克/千克。这两组中分别有42只和51只小鼠存活，在饮食中维生素E补充量低的组中，腺瘤更多、具有多形性细胞学特征的腺瘤更多，且浸润性癌更多。提示维生素E可能在饮食对结直肠癌发生的多因素影响中发挥一定作用。
