Wake Forest Institute for Regenerative Medicine, Winston Salem, NC, USA.
Ann Surg. 2012 May;255(5):867-80. doi: 10.1097/SLA.0b013e318243a4db.
The present review illustrates the state of the art of regenerative medicine (RM) as applied to surgical diseases and demonstrates that this field has the potential to address some of the unmet needs in surgery. RM is a multidisciplinary field whose purpose is to regenerate in vivo or ex vivo human cells, tissues, or organs to restore or establish normal function through exploitation of the potential to regenerate, which is intrinsic to human cells, tissues, and organs. RM uses cells and/or specially designed biomaterials to reach its goals and RM-based therapies are already in use in several clinical trials in most fields of surgery. The main challenges for investigators are threefold: Creation of an appropriate microenvironment ex vivo that is able to sustain cell physiology and function in order to generate the desired cells or body parts; identification and appropriate manipulation of cells that have the potential to generate parenchymal, stromal and vascular components on demand, both in vivo and ex vivo; and production of smart materials that are able to drive cell fate.
本文综述了再生医学在外科疾病中的应用现状，证明了该领域有潜力解决外科领域的一些未满足的需求。再生医学是一个多学科领域，其目的是通过利用人类细胞、组织和器官固有的再生潜力，在体内或体外再生人类细胞、组织或器官，以恢复或建立正常功能。再生医学使用细胞和/或专门设计的生物材料来实现其目标，基于再生医学的疗法已经在大多数外科领域的几个临床试验中使用。研究人员面临的主要挑战有三方面：体外创造一个合适的微环境，使其能够维持细胞的生理和功能，以生成所需的细胞或身体部位；鉴定和适当操作具有按需在体内和体外生成实质、基质和血管成分潜力的细胞；以及生产能够驱动细胞命运的智能材料。
