Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Lupus. 2012 Jul;21(8):836-9. doi: 10.1177/0961203312437438. Epub 2012 Feb 13.
Twenty-four hour urine collection has been the foundation for monitoring patients with lupus nephritis. However, the use of protein to creatinine ratios in spot urine samples is now widely used. We aimed to evaluate the validity of this method cross-sectionally and longitudinally.
A cross-sectional retrospective study was conducted. Records of 486 lupus nephritis patients were searched for paired results of 24-h quantification of urinary protein and a random spot urine protein to creatinine ratio and were examined over a three-year period.
Ninety-five lupus nephritis patients had paired results and were included in the final analysis, male/female 14/81, mean age 36.5 years. Over a three-year period there were a total of 137 samples from 95 patients. For the entire dataset, there was a significant correlation between protein:creatinine ratio and 24-h urine collection protein (mg), Spearman Rho correlation coefficient was 0.869, p < 0.0001 with (R (2 )= 0.504). There was also a strong correlation for longitudinal data, n = 14 at two-years Rho 0.910, p < 0.0001 with (R (2 )= 0.878), n = 8 at three-years Rho 0.909, p < 0.0001 and (R (2 )= 0.73). We have shown for the first time in a UK population of lupus nephritis patients, well trained in producing 24-h collection, that the spot protein:creatinine ratio correlates well with 24-h urinary total protein excretion. Having a simple, reliable, reproducible and cost-effective test such as the spot urine protein:creatinine ratio is therefore a valuable tool with which to monitor disease progression.
24 小时尿液收集一直是监测狼疮肾炎患者的基础。然而，现在广泛使用尿液标本中蛋白质与肌酐的比值。我们旨在评估该方法的横断面和纵向有效性。
进行了一项横断面回顾性研究。对 486 例狼疮肾炎患者的记录进行了搜索，以查找 24 小时定量尿蛋白和随机尿蛋白与肌酐比值的配对结果，并在三年内进行了检查。
95 例狼疮肾炎患者有配对结果，最终纳入 95 例患者的 137 个样本进行最终分析，其中男/女 14/81，平均年龄 36.5 岁。在三年内，95 例患者共有 137 个样本。对于整个数据集，蛋白：肌酐比值与 24 小时尿液收集蛋白（mg）之间存在显著相关性，Spearman Rho 相关系数为 0.869，p<0.0001（R (2)=0.504）。纵向数据也有很强的相关性，n=14 时两年 Rho 0.910，p<0.0001（R (2)=0.878），n=8 时三年 Rho 0.909，p<0.0001，（R (2)=0.73）。我们首次在英国狼疮肾炎患者人群中证明，经过良好的 24 小时收集训练，点尿蛋白：肌酐比值与 24 小时尿总蛋白排泄量密切相关。因此，拥有一种简单、可靠、可重复且具有成本效益的测试，如点尿蛋白：肌酐比值，是监测疾病进展的一种有价值的工具。
