Zhang Q, Sun L, Jin L
Department of Nephrology, Lishui Center Hospital, Lishui, China.
Department of Nephrology, Lishui Center Hospital, Lishui, China
Lupus. 2015 Aug;24(9):943-7. doi: 10.1177/0961203315570688. Epub 2015 Feb 9.
The aim of this study was to evaluate the correlation and agreement of spot urine protein/creatinine (P/C) ratio with 24 h proteinuria in patients with lupus nephritis (LN) under different scores of activity index (AI).
In total, 90 pairs of 24 h urine and spot urine samples from 90 patients with biopsy-proven LN were analyzed. The correlation and agreement between the two sample types were assessed by Pearson correlation and intra-class correlation coefficient (ICC) using mixed model for repeated measurements, respectively.
Overall, 24 h proteinuria correlated strongly with the spot urine P/C ratio (r = 0.671, p < 0.001) with a good agreement (ICC = 0.656, 95% confidence interval (CI): 0.52-0.76). Subgroup analyses revealed that the correlation remained high in all groups (r = 0.825, p < 0.001; r = 0.567, p = 0.001; r = 0.686, p = 0.020), the agreement in group A (low AI) was good (ICC = 0.824, 95% CI: 0.70-0.89), but in group B (middle AI) and group C (high AI), the agreements were weak (ICC = 0.503, 95% CI: 0.19-0.72; ICC = 0.532, 95% CI: 0.06-0.84). Our work suggests that over the range of a higher AI, however, correlation was present but agreement was poor.
本研究旨在评估狼疮性肾炎（LN）患者在不同活动指数（AI）评分下，随机尿蛋白/肌酐（P/C）比值与24小时蛋白尿之间的相关性和一致性。
共分析了90例经活检证实为LN患者的90对24小时尿液和随机尿液样本。分别采用Pearson相关性分析和重复测量混合模型的组内相关系数（ICC）评估两种样本类型之间的相关性和一致性。
总体而言，24小时蛋白尿与随机尿P/C比值高度相关（r = 0.671，p < 0.001），一致性良好（ICC = 0.656，95%置信区间（CI）：0.52 - 0.76）。亚组分析显示，所有组的相关性均较高（r = 0.825，p < 0.001；r = 0.567，p = 0.001；r = 0.686，p = 0.020），A组（低AI）的一致性良好（ICC = 0.824，95% CI：0.70 - 0.89），但B组（中AI）和C组（高AI）的一致性较弱（ICC = 0.503，95% CI：0.19 - 0.72；ICC = 0.532，95% CI：0.06 - 0.84）。我们的研究表明，然而，在较高AI范围内，存在相关性但一致性较差。
