Krishnan K R, Husain M M, McDonald W M, Doraiswamy P M, Figiel G S, Boyko O B, Ellinwood E H, Nemeroff C B
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710.
Life Sci. 1990;47(15):1325-9. doi: 10.1016/0024-3205(90)90196-x.
Using intermediate weighted magnetic resonance imaging (MRI) and a systematic sampling stereological method in 39 normal volunteers aged 24-79 years old, we demonstrated a marked age-associated decline in caudate nuclei volume (r = -0.69, p less than 0.0001). The mean absolute volume of the caudate nuclei in this study (9.4 cm3) was almost identical to that reported in a previous autopsy study and further confirms the validity of this stereological technique for use with MR images. This technique will provide a method for measuring the caudate and other nuclei in vivo, from brain images and, as such, a research tool to correlate age-associated changes in cognitive, sensory and motor function with caudate nucleus volume and other brain regions.
我们对39名年龄在24至79岁之间的正常志愿者，使用中等加权磁共振成像（MRI）和系统抽样立体学方法，结果显示尾状核体积随年龄增长显著下降（r = -0.69，p < 0.0001）。本研究中尾状核的平均绝对体积（9.4 cm³）与先前尸检研究报告的数值几乎相同，进一步证实了这种立体学技术用于磁共振图像的有效性。该技术将提供一种从脑图像中在体内测量尾状核及其他核团的方法，因此是一种将认知、感觉和运动功能的年龄相关变化与尾状核体积及其他脑区相关联的研究工具。
