Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, School of Medicine, Los Angeles, CA, USA.
Neurobiol Aging. 2010 Aug;31(8):1312-25. doi: 10.1016/j.neurobiolaging.2010.05.002. Epub 2010 Jun 11.
MRI research examining structural brain atrophy in Alzheimer's disease (AD) generally focuses on medial temporal and cortical structures, but amyloid and tau deposits also accumulate in the caudate. Here we mapped the 3D profile of caudate atrophy using a surface mapping approach in subjects with AD and mild cognitive impairment (MCI) to identify potential clinical and pathological correlates. 3D surface models of the caudate were automatically extracted from 400 baseline MRI scans (100 AD, 200 MCI, 100 healthy elderly). Compared to controls, caudate volumes were lower in MCI (2.64% left, 4.43% right) and AD (4.74% left, 8.47% right). Caudate atrophy was associated with age, sum-of-boxes and global Clinical Dementia Ratings, Delayed Logical Memory scores, MMSE decline 1 year later, and body mass index. Reduced right (but not left) volume was associated with MCI-to-AD conversion and CSF tau levels. Normal caudate asymmetry (with the right 3.9% larger than left) was lost in AD, suggesting preferential right caudate atrophy. Automated caudate maps may complement other MRI-derived measures of disease burden in AD.
MRI 研究通常侧重于检查阿尔茨海默病（AD）患者的内侧颞叶和皮质结构的脑萎缩，但淀粉样蛋白和 tau 沉积物也会在尾状核中积累。在这里，我们使用表面映射方法对 AD 和轻度认知障碍（MCI）患者的尾状核进行了 3D 形态分析，以确定潜在的临床和病理相关性。从 400 份基线 MRI 扫描（100 份 AD、200 份 MCI、100 份健康老年人）中自动提取了尾状核的 3D 表面模型。与对照组相比，MCI 组的尾状核体积较小（左侧为 2.64%，右侧为 4.43%），AD 组的尾状核体积较小（左侧为 4.74%，右侧为 8.47%）。尾状核萎缩与年龄、框和全局临床痴呆评定量表（Clinical Dementia Rating，CDR）总分、延迟逻辑记忆评分、1 年后 MMSE 下降以及体重指数有关。右侧（但不是左侧）体积的减少与 MCI 到 AD 的转换以及 CSF tau 水平有关。AD 患者的正常尾状核左右不对称（右侧比左侧大 3.9%）消失，提示右侧尾状核萎缩更明显。自动生成的尾状核图谱可能会补充 AD 中其他基于 MRI 的疾病负担测量方法。
