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三个地区人群唇裂严重程度的横断面比较。

A Cross-sectional Comparison of Cleft Lip Severity in 3 Regional Populations.

作者信息

Lanteri Alexis Caitlin, Parcells Bertrand William, Lizarraga Ana Karina, Magee William, Bermudez Luis

机构信息

Operation Smile, Inc, Norfolk, VA.

出版信息

Eplasty. 2012;12:e10. Epub 2012 Feb 3.

PMID:22331990
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3273313/
Abstract

OBJECTIVE

The purpose of this cross-sectional study was to compare the severity of unilateral cleft lips in populations of Asia, Sub-Saharan Africa, and Northern Africa and the Middle East. We hypothesize that severity of unilateral cleft lips shows significant variation between these populations.

METHODS

Medical photographs of 780 patients with primary unilateral cleft lips treated by Operation Smile during November 2007 were reviewed. Photographs of 352 patients from Asia (China, Philippines, Vietnam, Laos, and Cambodia), 112 patients from the Middle East and North Africa (Jordan, Egypt, and Morocco), and 316 patients from Sub-Saharan Africa (Ethiopia, Kenya, and Madagascar) were analyzed. The severity of cleft lips was determined using the Fisher method, which measures the columellar angle as a deviation of the columella from its normal vertical position. The angle was measured using a protractor with its base positioned along a line joining the lateral canthi. An analysis of variance calculated statistical differences between each region and their respective countries.

RESULTS

The Asian region was found to have the greatest severity of unilateral cleft lip deformity (P < .05). Analysis-of-variance tests show a significant difference between Asia and other regions studied. When stratifying the data by country, the Philippines and Vietnam showed the highest severity.

CONCLUSIONS

The results suggest a heterogeneous pattern of global severity. Unilateral cleft lips with the highest severity were predominant in the Asian region. The observed phenotypical differences can be used in future studies of gene variability or environmental factors to determine the cause of this significant disparity.

摘要

目的

本横断面研究旨在比较亚洲、撒哈拉以南非洲以及北非和中东地区单侧唇裂的严重程度。我们假设这些地区单侧唇裂的严重程度存在显著差异。

方法

回顾了2007年11月期间由“微笑行动”治疗的780例原发性单侧唇裂患者的医学照片。分析了来自亚洲（中国、菲律宾、越南、老挝和柬埔寨）的352例患者、来自中东和北非（约旦、埃及和摩洛哥）的112例患者以及来自撒哈拉以南非洲（埃塞俄比亚、肯尼亚和马达加斯加）的316例患者的照片。使用费舍尔方法确定唇裂的严重程度，该方法将鼻小柱角测量为鼻小柱与其正常垂直位置的偏差。使用量角器测量角度，量角器的底边沿着连接外眦的线放置。方差分析计算每个地区及其各自国家之间的统计差异。

结果

发现亚洲地区单侧唇裂畸形的严重程度最高（P < .05）。方差分析测试表明亚洲与其他研究地区之间存在显著差异。按国家对数据进行分层时，菲律宾和越南的严重程度最高。

结论

结果表明全球严重程度存在异质性模式。严重程度最高的单侧唇裂在亚洲地区占主导地位。观察到的表型差异可用于未来关于基因变异性或环境因素的研究，以确定这种显著差异的原因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bec9/3273313/2364a68fccea/eplasty12e10_fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bec9/3273313/493e41862fa3/eplasty12e10_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bec9/3273313/a4bf0eb9819f/eplasty12e10_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bec9/3273313/2be21c7a1079/eplasty12e10_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bec9/3273313/68f3a4208275/eplasty12e10_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bec9/3273313/2364a68fccea/eplasty12e10_fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bec9/3273313/493e41862fa3/eplasty12e10_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bec9/3273313/a4bf0eb9819f/eplasty12e10_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bec9/3273313/2be21c7a1079/eplasty12e10_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bec9/3273313/68f3a4208275/eplasty12e10_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bec9/3273313/2364a68fccea/eplasty12e10_fig5.jpg

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本文引用的文献

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2
Folic acid and orofacial clefts: a review of the evidence.叶酸与口腔颌面部裂：证据回顾。
Oral Dis. 2010 Jan;16(1):11-9. doi: 10.1111/j.1601-0825.2009.01587.x.
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Autoantibodies to folate receptor alpha during early pregnancy and risk of oral clefts in Denmark.早孕期抗叶酸受体α自身抗体与丹麦口腔裂风险。
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Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip.IRF6增强子中AP - 2α结合位点的破坏与唇裂相关。
Nat Genet. 2008 Nov;40(11):1341-7. doi: 10.1038/ng.242. Epub 2008 Oct 5.
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