Zhong S, Almario R, Dubrinsky M, Rose K, Lin P K, Grunberger G, Jen K L
Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48202.
Metabolism. 1990 Nov;39(11):1127-32. doi: 10.1016/0026-0495(90)90083-o.
Repeated pregnancy without lactation in rats has been reported to produce permanently elevated carcass fat mass and hyperplasia in subcutaneous fat depot. In the present study, the pregnancy outcome, intravenous glucose tolerance ability (IVGTT), and carcass composition were further examined in Osborne-Mendel rats. Female rats were divided into pregnancy-lactation (PL), pregnancy-no lactation (PNL), and control (CON) groups. Half of the rats were killed after three pregnancy/lactation cycles, whereas the rest were given a 12-week rest period before killing. It was found that rats in PNL group had fasting hyperglycemia and insulin insensitivity during the third pregnancy (P less than or equal to .05), elevated spontaneous abortion rate (P less than or equal to .05), and elevated subcutaneous fat content (P less than or equal to .01) relative to that of PL rats or CON rats. After a 12-week rest period, a significant increase in subcutaneous fat cell number was also observed in PNL rats. PL rats, on the other hand, have significantly elevated internal/subcutaneous fat ratios (P less than or equal to .05), both immediately after weaning and after the 12-week rest period. The significance of this change is not yet known.
据报道，大鼠反复怀孕且不哺乳会导致体脂量永久性增加以及皮下脂肪库增生。在本研究中，对奥斯本-孟德尔大鼠的妊娠结局、静脉葡萄糖耐量能力（IVGTT）和身体组成进行了进一步研究。将雌性大鼠分为妊娠-哺乳（PL）组、妊娠-不哺乳（PNL）组和对照组（CON）。一半大鼠在经历三个妊娠/哺乳周期后处死，而其余大鼠在处死前给予12周的休息期。结果发现，与PL组大鼠或CON组大鼠相比，PNL组大鼠在第三次妊娠期间出现空腹高血糖和胰岛素不敏感（P≤0.05），自然流产率升高（P≤0.05），皮下脂肪含量升高（P≤0.01）。在12周的休息期后，PNL组大鼠的皮下脂肪细胞数量也显著增加。另一方面，PL组大鼠在断奶后和12周休息期后，内脏/皮下脂肪比率均显著升高（P≤0.05）。这种变化的意义尚不清楚。
