Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
J Am Chem Soc. 2012 Mar 7;134(9):4104-7. doi: 10.1021/ja300552c. Epub 2012 Feb 22.
An efficient rhodium-catalyzed synthesis of 2H-azirines and pyrroles has been developed. Novel rearrangement of α-oximino ketenes derived from α-diazo oxime ethers provides 2H-azirines bearing quaternary centers and allows for subsequent rearrangement to highly substituted pyrroles in excellent yields.
一种高效的铑催化合成 2H-氮丙啶和吡咯的方法已经被开发出来。新型α-氧亚氨基烯酮的重排反应，来源于α-重氮肟醚，提供了带有季碳原子的 2H-氮丙啶，并允许随后重排，以优异的收率得到高取代的吡咯。
