The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Nutr Cancer. 2012 Apr;64(3):368-76. doi: 10.1080/01635581.2012.654586. Epub 2012 Feb 14.
Titanium and vanadium are essential trace elements. This study examined the associations of urinary titanium and vanadium with breast cancer risk in a hospital-based case-control study comprising 240 women with incident breast cancer, and 246 cancer-free and age-matched controls who attended health screening assessments in 2 affiliated hospitals of Sun Yat-sen University in Guangzhou between October 2009 and July 2010. Survey data and urine specimens were collected before treatment for the patients and after interview for the controls. The urinary concentrations of titanium and vanadium were measured by inductively coupled plasma mass spectrometry. Women in the second and the highest tertile of vanadium showed 64% and 40% decreased risk of breast cancer, respectively, when compared with those in the lowest tertile after adjustment for established risk factors of breast cancer (ORs [95%CI]: 0.36 [0.21-0.60] and 0.60 [0.37-0.97], respectively). In contrast, urinary titanium was not significantly related to a decreased risk of breast cancer. These results have potentially significant implications on nutritional chemoprevention of breast cancer and the development of new anticancer drugs. Further replications of the study are recommended, and the biological mechanisms warrant clarification.
钛和钒是必需的微量元素。本研究通过一项以医院为基础的病例对照研究，分析了尿钛和钒与乳腺癌风险的相关性。该研究纳入了 240 名 2009 年 10 月至 2010 年 7 月在中山大学两所附属医院参加健康筛查的新发乳腺癌女性患者，以及 246 名年龄匹配且无癌症的对照组女性。在治疗前收集了患者的调查数据和尿样，在访谈后收集了对照组女性的尿样。采用电感耦合等离子体质谱法测定尿钛和钒的浓度。校正乳腺癌的已知危险因素后，与尿钒最低三分位组相比，尿钒第二和最高三分位组的女性患乳腺癌的风险分别降低了 64%和 40%（OR[95%CI]：0.36[0.21-0.60]和 0.60[0.37-0.97]）。相反，尿钛与乳腺癌风险降低无显著相关性。这些结果对乳腺癌的营养化学预防和新型抗癌药物的开发具有潜在的重要意义。建议进一步开展研究进行验证，并阐明其生物学机制。
