UMR190 Emergence des Pathologies Virales, Aix-Marseille Université, Institut de Recherche pour le Développement, EHESP French School of Public Health, Marseille, France.
Clin Microbiol Infect. 2012 Apr;18(4):E77-80. doi: 10.1111/j.1469-0691.2012.03769.x. Epub 2012 Feb 14.
Enterovirus-positive samples diagnosed in Marseille (January 2009 to September 2011) were screened for EV71 by real-time RT-PCR. EV71 was detected in three children below the age of 2 years with no history of overseas travel; two of these cases were associated with severe clinical presentation. Viruses demonstrated genetic similarity to other European genogroup C2 strains. Strain MRS/09/3663 complete sequencing revealed 97.6% identity across the entire genome with a 2008 Singapore isolate, without signs of possible recombination events. To our knowledge, this is the first detection of EV71 infection in Marseille, France, that confirms the current circulation of EV71 in France.
2009 年 1 月至 2011 年 9 月在马赛诊断为肠道病毒阳性的样本，用实时 RT-PCR 进行肠道病毒 71 型的检测。在无出国旅行史的 3 名 2 岁以下儿童中检测到肠道病毒 71 型；其中 2 例与严重临床表现相关。这些病毒与其他欧洲 C2 基因型株具有遗传相似性。MRS/09/3663 株的全序列测序显示，整个基因组与 2008 年新加坡分离株的同源性为 97.6%，没有可能的重组事件的迹象。据我们所知，这是法国马赛首次检测到肠道病毒 71 型感染，证实肠道病毒 71 型在法国的传播。
