Ishizawa Yoshiya, Aizawa Shunji, Okudera Dai, Yokoyama Makoto, Aizawa Hiroshi, Satoh Yuki, Kasai Masaharu, Munakata Masaki, Sakata Yu, Hakamada Kenichi
Dept. of Surgery, Misawa City Hospital, Japan.
Gan To Kagaku Ryoho. 2012 Feb;39(2):289-92.
The patient was a 67-year-old male with type-3 gastric cancer from the upper body of the stomach to the cardia. An abdominal computed tomography scan revealed liver metastases(S8)(T2N0M0H1, Stage IV). The patient received neoadjuvant combined chemotherapy with S-1 and CDDP. S-1(120mg/body/day)was orally administered for 3 weeks followed by 2 drug-free weeks as a course, and CDDP(60mg/m2)was administered by intravenous infusion on day 8. After the second course, significant tumor reduction and disappearance of liver metastases resulted. Total gastrectomy, splenectomy, cholecystectomy, and D2 nodal dissection were performed. The histological diagnosis revealed no metastases in all lymph nodes: Stage I B. The combined neoadjuvant chemotherapy with S-1 and CDDP can be considered an effective treatment for advanced gastric cancer.
该患者为67岁男性，患有从胃上部至贲门的3型胃癌。腹部计算机断层扫描显示肝转移（S8）（T2N0M0H1，IV期）。患者接受了S-1和顺铂的新辅助联合化疗。S-1（120mg/体/天）口服3周，随后停药2周为一个疗程，顺铂（60mg/m²）在第8天静脉输注。第二个疗程后，肿瘤显著缩小，肝转移消失。进行了全胃切除术、脾切除术、胆囊切除术和D2淋巴结清扫术。组织学诊断显示所有淋巴结均无转移：I B期。S-1和顺铂联合新辅助化疗可被认为是晚期胃癌的有效治疗方法。
