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帕金森病与细胞色素P450:可能存在联系?

Parkinson's disease and cytochrome P450: a possible link?

作者信息

Shahi G S, Das N P, Moochhala S M

机构信息

Department of Physiology, National University of Singapore.

出版信息

Med Hypotheses. 1990 Aug;32(4):277-82. doi: 10.1016/0306-9877(90)90106-o.

DOI:10.1016/0306-9877(90)90106-o
PMID:2233418
Abstract

The possibility that idiopathic Parkinson's disease may be linked to a deficiency of an important detoxifying enzyme such as the cytochrome P450 enzyme bufuralol hydroxylase is examined. A hypothetical model of how this might operate to produce early onset Parkinson's disease is suggested.

摘要

研究了特发性帕金森病可能与一种重要的解毒酶如细胞色素P450酶布福洛尔羟化酶缺乏有关的可能性。提出了一个关于这可能如何导致早发性帕金森病的假说模型。

相似文献

1
Parkinson's disease and cytochrome P450: a possible link?帕金森病与细胞色素P450:可能存在联系?
Med Hypotheses. 1990 Aug;32(4):277-82. doi: 10.1016/0306-9877(90)90106-o.
2
Studies on the interactions of MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) with the cytochrome P-450 enzyme system--clues to a possible aetiological factor in Parkinson's disease.1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)与细胞色素P-450酶系统相互作用的研究——帕金森病潜在病因线索
Ann Acad Med Singap. 1989 Jan;18(1):93-7.
3
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4--implications for susceptibility to Parkinson's disease.1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)可被细胞色素P450 2D6、1A2和3A4去甲基化——对帕金森病易感性的影响
J Pharmacol Exp Ther. 1996 May;277(2):685-90.
4
Tyrosine hydroxylase and parkinsonism.酪氨酸羟化酶与帕金森病
Lancet. 1971 Jul 17;2(7716):165. doi: 10.1016/s0140-6736(71)92339-7.
5
MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation.
Biochem Biophys Res Commun. 1987 Nov 13;148(3):1144-50. doi: 10.1016/s0006-291x(87)80252-8.
6
[Search for the cause of Parkinson's disease].
Arch Neurobiol (Madr). 1991 Nov-Dec;54(6):264-71.
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The MPTP model of Parkinson's disease.帕金森病的MPTP模型。
Brain Res Mol Brain Res. 2005 Mar 24;134(1):57-66. doi: 10.1016/j.molbrainres.2004.09.017.
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Debrisoquine hydroxylation in Parkinson's disease.帕金森病中的异喹胍羟基化作用
Acta Neurol Scand. 1992 Aug;86(2):159-64. doi: 10.1111/j.1600-0404.1992.tb05059.x.
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The MPTP tale: pathway to prevention of Parkinson's disease?
Br J Hosp Med. 1993;49(10):716-9.
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Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease.异喹胍羟化酶基因多态性与帕金森病易感性
Lancet. 1992 Jun 6;339(8806):1375-7. doi: 10.1016/0140-6736(92)91196-f.

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