Departamento de Psicobiologia, Universidade Federal de São Paulo, Rua Professor Francisco de Castro, 93 Vila Clementino, CEP 04020-050, São Paulo, SP, Brazil.
Muscle Nerve. 2012 Mar;45(3):431-3. doi: 10.1002/mus.22322.
Because paradoxical sleep deprivation (PSD) induces a catabolic hormone profile, we sought to evaluate the morphology of the tibialis anterior (TA) muscle and testosterone and corticosterone levels of paradoxical sleep-deprived rats.
Three study groups of rats were established: the first group was sleep deprived for 96 h; the second group was also sleep deprived for 96 h, but then returned to their home-cage and allowed to sleep for the next 96 h; and the third group was the control group, with a normal sleep cycle.
PSD reduced the weight and fiber cross-sectional area of the TA muscle. Moreover, PSD enhanced plasma corticosterone and reduced serum testosterone levels. The 96 h of sleep after PSD was sufficient to restore partially the morphology of TA, while hormones returned to basal levels.
PSD induces hormonal alterations that may mediate muscle atrophy.
由于矛盾性睡眠剥夺（PSD）会诱导分解代谢激素谱，我们试图评估胫骨前肌（TA）的形态和矛盾性睡眠剥夺大鼠的睾酮和皮质酮水平。
建立了三组大鼠研究组：第一组被剥夺睡眠 96 小时；第二组也被剥夺睡眠 96 小时，但随后返回其巢箱并允许再睡眠 96 小时；第三组为对照组，具有正常的睡眠周期。
PSD 降低了 TA 肌肉的重量和纤维横截面积。此外，PSD 增加了血浆皮质酮并降低了血清睾酮水平。PSD 后 96 小时的睡眠足以部分恢复 TA 的形态，而激素则恢复到基础水平。
PSD 引起的激素变化可能介导肌肉萎缩。
