白细胞介素6表达与非小细胞肺癌患者临床特征之间相关性的意义。

Significance of the correlation between the expression of interleukin 6 and clinical features in patients with non-small cell lung cancer.

作者信息

Koh Eitetsu, Iizasa Toshihiko, Yamaji Haruko, Sekine Yasuo, Hiroshima Kenzo, Yoshino Ichiro, Fujisawa Takehiko

机构信息

Department of Thoracic Surgery, Tokyo Women's Medical University Yachiyo Medical Center, Owada-Shinden Yachiyo City, Chiba, Japan.

出版信息

Int J Surg Pathol. 2012 Jun;20(3):233-9. doi: 10.1177/1066896911436274. Epub 2012 Feb 13.

DOI:10.1177/1066896911436274

PMID:22334615

Abstract

BACKGROUND

The aims of the study were to identify the significance of interleukin (IL)-6 production and to determine whether IL-6 production influences long-term survival in patients with non-small-cell lung cancer (NSCLC).

METHOD

A series of 90 patients with NSCLC who underwent surgery between 2005 and 2007 was analyzed. Preoperative serum IL-6 was measured, and tumor samples were immunohistochemically stained for IL-6.

RESULTS

Serum IL-6 levels were elevated in 43 of 90 cases (47.7%), and 23 (25.5%) of 90 cases stained positively for IL-6 (P = .00265). The prognosis of patients with NSCLC who had positive immunohistochemical staining was significantly worse than that for those who had negative staining, by univariate analysis (P = .0027). Multivariate analysis indicated that tumor size, postoperative stage, and overexpression of IL-6 were independent prognostic factors.

CONCLUSIONS

The expression of IL-6 in tumor correlated with the concentration of serum IL-6, tumor progression, and overall survival in patients with NSCLC.

摘要

背景

本研究的目的是确定白细胞介素（IL）-6产生的意义，并确定IL-6的产生是否影响非小细胞肺癌（NSCLC）患者的长期生存。

方法

分析了2005年至2007年间接受手术的90例NSCLC患者。测量术前血清IL-6，并对肿瘤样本进行IL-6免疫组化染色。

结果

90例中有43例（47.7%）血清IL-6水平升高，90例中有23例（25.5%）IL-6免疫组化染色呈阳性（P = 0.00265）。单因素分析显示，免疫组化染色阳性的NSCLC患者预后明显差于染色阴性患者（P = 0.0027）。多因素分析表明，肿瘤大小、术后分期和IL-6过表达是独立的预后因素。