Division of Geriatrics, Howard University Hospital, Washington, DC 20060, USA.
Clin Interv Aging. 2012;7:35-43. doi: 10.2147/CIA.S26794. Epub 2012 Jan 31.
To test the hypothesis that aerobic-related leisure-time physical activity (PA) is associated with better cognitive function and that the effect varies among apolipoprotein E (APOE) genotype groups.
Cross-sectional study of persons examined in the Third National Health and Nutrition Examination Survey (NHANES-III; 1988-1994).
US noninstitutionalized population.
From a sample of 7159, aged ≥60 years, we analyzed data for 1799 older American men and women who had information on PA, a short mental status examination (SMSE), and were genotyped at the apolipoprotein E gene locus.
In the initial bivariate analysis, non-ɛ4 carriers and ɛ4-heterozygotes performed better than ɛ4-homozygotes in the 60-69 age group. After controlling for multiple confounders including mobility limitation, PA correlated with a higher SMSE score in non-ɛ4 carriers (P = 0.014), but not in ɛ4 carriers (P = 0.887). At ≥70 years, PA also correlated with higher adjusted SMSE scores in non-ɛ4 carriers (P = 0.02); but this association became nonsignificant after controlling for mobility limitation (P = 0.12).
In a nationally representative sample, PA was associated with enhanced cognition, an effect that was differentially influenced by apolipoprotein E genotype. Experimental studies are needed to determine whether or not PA can attenuate cognitive decline.
检验有氧运动相关的闲暇时间体力活动（PA）与更好的认知功能相关，以及这种效应在载脂蛋白 E（APOE）基因型群体中存在差异的假设。
对第三次国家健康和营养检查调查（NHANES-III；1988-1994 年）中检查的人群进行的横断面研究。
美国非机构化人群。
从一个 7159 人的样本中，年龄≥60 岁，我们分析了 1799 名年龄较大的美国男性和女性的数据，他们有关于 PA、简短心理状态检查（SMSE）的信息，并且在载脂蛋白 E 基因座上进行了基因分型。
在初始的双变量分析中，非ɛ4 携带者和ɛ4-杂合子在 60-69 岁年龄组的表现优于ɛ4-纯合子。在控制了包括行动能力受限在内的多个混杂因素后，PA 与非ɛ4 携带者的 SMSE 评分较高相关（P=0.014），但与ɛ4 携带者无关（P=0.887）。在≥70 岁时，PA 也与非ɛ4 携带者的调整后 SMSE 评分较高相关（P=0.02）；但在控制了行动能力受限后，这种相关性变得无统计学意义（P=0.12）。
在一个具有代表性的全国性样本中，PA 与增强的认知能力相关，这种效应受到载脂蛋白 E 基因型的不同影响。需要进行实验研究以确定 PA 是否可以减缓认知能力下降。
