Loc-Carrillo Catherine, Abedon Stephen T
Department of Orthopaedics; The University of Utah; Salt Lake City, UT USA.
Bacteriophage. 2011 Mar;1(2):111-114. doi: 10.4161/bact.1.2.14590.
Many publications list advantages and disadvantages associated with phage therapy, which is the use of bacterial viruses to combat populations of nuisance or pathogenic bacteria. The goal of this commentary is to discuss many of those issues in a single location. In terms of "Pros," for example, phages can be bactericidal, can increase in number over the course of treatment, tend to only minimally disrupt normal flora, are equally effective against antibiotic-sensitive and antibiotic-resistant bacteria, often are easily discovered, seem to be capable of disrupting bacterial biofilms, and can have low inherent toxicities. In addition to these assets, we consider aspects of phage therapy that can contribute to its safety, economics, or convenience, but in ways that are perhaps less essential to the phage potential to combat bacteria. For example, autonomous phage transfer between animals during veterinary application could provide convenience or economic advantages by decreasing the need for repeated phage application, but is not necessarily crucial to therapeutic success. We also consider possible disadvantages to phage use as antibacterial agents. These "Cons," however, tend to be relatively minor.
许多出版物都列出了与噬菌体疗法相关的优缺点，噬菌体疗法是利用细菌病毒来对抗有害或致病细菌群体。本评论的目的是在一个地方讨论其中的许多问题。例如，在“优点”方面，噬菌体具有杀菌作用，在治疗过程中数量会增加，往往只会对正常菌群造成最小程度的破坏，对抗生素敏感菌和耐药菌同样有效，通常很容易被发现，似乎能够破坏细菌生物膜，并且固有毒性较低。除了这些优点外，我们还考虑了噬菌体疗法在安全性、经济性或便利性方面的一些因素，但这些因素对噬菌体对抗细菌的潜力来说可能并非至关重要。例如，在兽医应用中动物之间的自主噬菌体转移可以通过减少重复应用噬菌体的需求而提供便利或经济优势，但对治疗成功不一定至关重要。我们还考虑了将噬菌体用作抗菌剂可能存在的缺点。然而，这些“缺点”往往相对较小。
