Reutskiĭ I A, Gornostaĭ Z I
Med Parazitol (Mosk). 1990 Jul-Aug(4):5-7.
415 nonimmune patients with acute signs and symptoms of falciparum malaria have been examined. The study has shown that 2/3 of patients had a moderate form of the disease, a severe form was noted only in 4.57% of patients. Classical symptoms of malaria--chill, body ache, headache--were observed only in half of the patients, 1/3 of patients had so-called masks of malaria--respiratory catarrh, pharyngitis, allergy, symptoms of enterocolitis. Early diagnosis and complex treatment with chloroquine or chloroquine combined with fansidar (1.16% of patients) promoted to a rapid improvement of the clinical symptoms and to favourable outcome. No fatal outcomes or severe complications have been observed. The mean duration of the disability period was 8.9 days. The first-degree resistance to chloroquine (clinical data) was noted in 11 patients, repeated manifestations of malaria occurred in 8.12% of patients and were more severe.
对415名出现恶性疟原虫急性体征和症状的非免疫患者进行了检查。研究表明，2/3的患者患有中度疟疾，仅4.57%的患者为重度疟疾。只有一半的患者出现了疟疾的典型症状——寒战、身体疼痛、头痛，1/3的患者有所谓的疟疾伪装症状——呼吸道卡他、咽炎、过敏、小肠结肠炎症状。早期诊断并用氯喹或氯喹联合 Fansidar（1.16%的患者）进行综合治疗，促使临床症状迅速改善并取得良好预后。未观察到死亡病例或严重并发症。残疾期的平均时长为8.9天。11名患者出现了对氯喹的一级耐药（临床数据），8.12%的患者疟疾复发，且症状更为严重。
