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J Affect Disord. 2012 Apr;138(1-2):41-5. doi: 10.1016/j.jad.2011.12.037. Epub 2012 Feb 14.
Depressive disorders affect approximately 18.8 million patients annually. Influenza, a preventable infectious disease, leads to 50 million new cases each year and up to 40,000 deaths annually. It is believed that depressive symptoms somatize and can lead to decreased immune function. This hypothesis has little or no in vivo evidence. The purpose of this study was to investigate evidence in the literature of a correlation between depression and infection with influenza.
The databases PsycINFO, MEDLINE, IPA, and EMBASE were searched with search terms and keywords for "influenza" and "depression" or any derivation. Articles included in the search were required to be in English and conducted in human subjects.
Our search identified 799 unique articles that related depression and influenza. After an abstract review, full article evaluation, and inclusion/exclusion criteria were applied, 10 articles remained. Of the 10 articles evaluated, 70% of the papers concluded no difference in hemagluttinin levels between depressed and non-depressed patients.
We believe this systematic review is the first to investigate the correlation of influenza infection and depression. Our search resulted in little scientific evidence and, therefore, the risk of influenza in patients with depression cannot be determined.
抑郁障碍每年影响约 1880 万患者。流感是一种可预防的传染病，每年导致 5000 万例新发病例和多达 4 万人死亡。据信，抑郁症状会表现为躯体化症状，导致免疫功能下降。这一假说几乎没有或没有体内证据。本研究旨在调查文献中抑郁与流感感染之间相关性的证据。
使用“流感”和“抑郁”或任何派生词的检索词和关键词，在 PsycINFO、MEDLINE、IPA 和 EMBASE 数据库中进行检索。纳入的检索文章必须为英文，且为人体研究。
我们的检索共确定了 799 篇与抑郁和流感相关的独特文章。经过摘要审查、全文评估以及纳入/排除标准后，仍有 10 篇文章入选。在评估的 10 篇文章中，70%的论文得出结论，抑郁和非抑郁患者的血凝素水平没有差异。
我们认为这是首次系统地调查流感感染与抑郁之间相关性的研究。我们的检索结果几乎没有科学证据，因此无法确定流感在抑郁症患者中的风险。
