Huang Wen, Wang Hong-yuan, Wang Qi
Department of Toxicology, School of Public Health, Peking University, Beijing 100191, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2011 Nov;45(11):1031-5.
Synthesize the relevant research and then discuss the influence of inhalable particulate matter (PM(10)) on mortality by exposure-response analysis.
The eligible research papers which studied the association between PM(10) and overall mortality of residents, the mortality of cardiovascular and cerebrovascular diseases and the mortality of respiratory diseases; and 21 pieces of the papers were adopted in this study. The papers were analyzed by Stata 9.0 software, and the exposure-response coefficient of PM(10) and mortality were extracted. The effect size was amalgamated by fixed or random effects, and the sensitivity analysis and publication bias of the results were detected and adjusted.
Each 10 µg/m(3) increase of PM(10) was associated with estimated relative risk (RR) of daily all-course mortality, the mortality of cardiovascular and cerebrovascular diseases and the mortality of respiratory diseases at 1.0033 (95%CI: 1.0022 - 1.0044), 1.0045 (95%CI: 1.0029 - 1.0062) and 1.0056 (95%CI: 1.0033 - 1.0079), respectively. After the publication bias was adjusted, the RR of daily all-cause, cardiovascular and cerebrovascular diseases and respiratory diseases mortality was reduced to 1.0012 (95%CI: 1.0002 - 1.0022), 1.0011 (95%CI: 0.9996 - 1.0026) and 1.0023 (95%CI: 1.0001 - 1.0045).
The increase of the concentration of PM(10) led to the increase of the daily all-course mortality, the mortality of cardiovascular and cerebrovascular diseases and the mortality of respiratory diseases.
综合相关研究，通过暴露-反应分析探讨可吸入颗粒物（PM10）对死亡率的影响。
纳入研究PM10与居民全因死亡率、心脑血管疾病死亡率及呼吸系统疾病死亡率之间关联的合格研究论文；本研究共采用21篇论文。运用Stata 9.0软件对论文进行分析，提取PM10与死亡率的暴露-反应系数。采用固定效应或随机效应合并效应量，并对结果进行敏感性分析和发表偏倚检测与校正。
PM10每增加10 μg/m³，与每日全因死亡率、心脑血管疾病死亡率及呼吸系统疾病死亡率的估计相对危险度（RR）分别为1.0033（95%CI：1.0022 - 1.0044）、1.0045（95%CI：1.0029 - 1.0062）和1.0056（95%CI：1.0033 - 1.0079）。校正发表偏倚后，每日全因、心脑血管疾病及呼吸系统疾病死亡率的RR分别降至1.0012（95%CI：1.0002 - 1.0022）、1.0011（95%CI：0.9996 - 1.0026）和1.0023（95%CI：1.0001 - 1.0045）。
PM10浓度升高导致每日全因死亡率、心脑血管疾病死亡率及呼吸系统疾病死亡率增加。
