Department of Cardiology, Institute of Cardiovascular Diseases, the First Affiliated Hospital, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, People's Republic of China.
Lipids Health Dis. 2012 Feb 15;11:26. doi: 10.1186/1476-511X-11-26.
TaqIB polymorphism in the cholesteryl ester transfer protein (CETP) gene has been reported to be associated with serum high-density lipoprotein cholesterol (HDL-C) levels and longevity in several populations, but controversial results also arose probably due to racial/ethnic diversity. Bama is a remote and mountainous county located in the northwest of Guangxi, People's Republic of China, which has been well known for its longevity for centuries. The current study was to investigate the possible association of CETP TaqIB polymorphism with serum lipid levels and longevity in the Bama Zhuang population.
The CETP TaqIB genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism in 523 long-lived inhabitants (long-lived group, LG; aged 90-107 years) and 498 healthy controls without longevity family history (non-long-lived group, non-LG; aged 40-69 years) residing in Bama County.
The levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were higher but TG, HDL-C/LDL-C ratio and the prevalence of dyslipidemia were lower in LG than in non-LG (P < 0.001 for all). There were no differences in the allelic and genotypic frequencies between the two groups (P > 0.05). Serum HDL-C levels and HDL-C/LDL-C ratio in LG were different among the genotypes (P < 0.01 for each), the subjects with B2B2 and B1B2 genotyes had higher HDL-C levels and HDL-C/LDL-C ratio than the subjects with B1B1genotye, whereas the levels of TC and HDL-C in non-LG were different among/between the genotypes (P < 0.01 for each), the B2 allele carriers had lower TC and higher HDL-C levels than the B2 allele noncarriers. Serum TG and HDL-C levels and HDL-C/LDL-C ratio were correlated with genotypes in LG, whereas serum TC and HDL-C levels were associated with genotypes in non-LG (P < 0.05-0.001).
The association of CETP TaqIB polymorphism and serum lipid profiles is different between LG and non-LG in the Chinese Bama Zhuang population. CETP TaqIB polymorphism might be one of the longevity-related genetic factors in this population.
胆固醇酯转移蛋白（CETP）基因中的 TaqIB 多态性已被报道与几种人群的血清高密度脂蛋白胆固醇（HDL-C）水平和长寿有关，但由于种族/民族多样性，也出现了有争议的结果。巴马是中国广西西北部的一个偏远山区县，几个世纪以来一直以长寿而闻名。本研究旨在探讨 CETP TaqIB 多态性与巴马壮族人群的血脂水平和长寿之间的可能关联。
采用聚合酶链反应和限制性片段长度多态性技术，在 523 名长寿居民（长寿组，LG；年龄 90-107 岁）和 498 名无长寿家族史的健康对照者（非长寿组，非 LG；年龄 40-69 岁）中检测 CETP TaqIB 基因型。
LG 组的总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）水平较高，但甘油三酯（TG）、HDL-C/LDL-C 比值和血脂异常的患病率较低（均 P<0.001）。两组间等位基因和基因型频率无差异（均 P>0.05）。LG 组中不同基因型的血清 HDL-C 水平和 HDL-C/LDL-C 比值不同（均 P<0.01），B2B2 和 B1B2 基因型的受试者 HDL-C 水平和 HDL-C/LDL-C 比值高于 B1B1 基因型的受试者，而非 LG 组中 TC 和 HDL-C 水平在不同/之间的基因型之间存在差异（均 P<0.01），B2 等位基因携带者的 TC 水平较低，HDL-C 水平较高，而非 B2 等位基因携带者。LG 组中血清 TG 和 HDL-C 水平和 HDL-C/LDL-C 比值与基因型相关，而非 LG 组中血清 TC 和 HDL-C 水平与基因型相关（均 P<0.05-0.001）。
中国巴马壮族人群中，LG 和非 LG 之间 CETP TaqIB 多态性与血脂谱的关联不同。CETP TaqIB 多态性可能是该人群长寿相关遗传因素之一。
