Psychopharmacology Unit, University of Bristol, UK.
Alcohol Alcohol. 2012 May-Jun;47(3):267-72. doi: 10.1093/alcalc/ags010. Epub 2012 Feb 14.
Ethyl glucuronide (EtG) in hair is a proposed biomarker for alcohol consumption. This study compares hair EtG concentrations with self-reported alcohol consumption data, in individuals with a range of alcohol use.
Hair was collected from 100 participants with a range of alcohol use. Participants completed an Alcohol Use Disorders Identification Test C questionnaire to record alcohol consumption. Participants were categorized into one of the four groups: tee-totallers (consuming 0 units a week), lower-risk drinkers (1-21 units a week), increasing-risk drinkers' consuming (22-50 units a week) and high-risk drinkers (over 50 units a week). Hair from the proximal 3 cm was analysed for EtG using gas chromatography-mass spectrometry/mass spectrometry.
EtG was detected in 29 out of 100 hair samples. Based on the Society of Hair Testing (SOHT) threshold of 30 pg/mg EtG, the hair test identified alcohol consumption in 57.9% of high-risk drinkers, 45.5% of increasing-risk drinkers and only 9.8% of lower-risk drinkers. EtG sensitivity was highest for high-risk drinkers (consuming more than 50 units a week), identified to be 0.52 using a 30 pg/mg threshold and 0.58 using a 45 pg/mg threshold. A positive result is highly likely to indicate any drinking (positive predictive value, 1.00). A negative result does not provide good evidence for abstinence (negative predictive value, 0.23).
EtG has been identified to be a low sensitivity marker that cannot be used quantitatively to determine alcohol exposure. EtG can be used qualitatively to indicate alcohol consumption with a positive result providing strong evidence for an individual drinking within the past 3 months.
毛发中的乙基葡萄糖醛酸苷（EtG）被提议作为酒精摄入的生物标志物。本研究比较了不同饮酒量个体的毛发 EtG 浓度与自我报告的酒精摄入量数据。
从 100 名具有不同饮酒量的参与者中采集毛发。参与者完成了酒精使用障碍识别测试 C 问卷，以记录饮酒量。参与者被分为以下四个组之一：滴酒不沾者（每周摄入 0 个单位）、低风险饮酒者（每周 1-21 个单位）、饮酒量逐渐增加者（每周 22-50 个单位）和高风险饮酒者（每周超过 50 个单位）。使用气相色谱-质谱/质谱法分析近端 3 厘米的毛发中的 EtG。
在 100 个毛发样本中，有 29 个检测到 EtG。根据头发测试协会（SOHT）30pg/mg EtG 的阈值，该毛发测试在 57.9%的高风险饮酒者、45.5%的饮酒量逐渐增加者和仅 9.8%的低风险饮酒者中识别出酒精摄入。对于高风险饮酒者（每周摄入超过 50 个单位），使用 30pg/mg 阈值的灵敏度最高，为 0.52，使用 45pg/mg 阈值的灵敏度为 0.58。阳性结果极有可能表明有任何饮酒（阳性预测值，1.00）。阴性结果并不能为禁欲提供良好的证据（阴性预测值，0.23）。
EtG 被确定为一种低灵敏度的标志物，不能用于定量确定酒精暴露。EtG 可用于定性指示酒精摄入，阳性结果为个体在过去 3 个月内饮酒提供了有力证据。
