Oklahoma State University Center for Health Sciences, National Center for Wellness & Recovery, Tulsa, OK, USA.
Integrative Immunology Lab, Department of Surgery, University of Oklahoma-Tulsa, Tulsa, OK, USA.
Neuropsychopharmacol Rep. 2021 Jun;41(2):144-151. doi: 10.1002/npr2.12151. Epub 2021 Mar 2.
The present study aimed to evaluate the validity of hair ethyl glucuronide concentrations compared with transdermal alcohol concentration and self-reported alcohol use.
This trial included 25 adolescent and young adult females, aged 16-24, who reported at least one heavy drinking episode (≥4 drinks) in the two weeks prior to baseline. All participants were asked to wear an alcohol biosensor over a one-month prospective study. Detailed self-report of drinking behaviors was assessed weekly. Estimates of blood alcohol concentration were computed from self-report data using the National Highway and Transportation Safety Administration equation. Transdermal alcohol concentration and estimated blood alcohol concentration data were categorized into at-risk (>0.05 g/dL alcohol) and high-risk (>0.08 g/dL alcohol) drinking events. Hair ethyl glucuronide concentration, total number of drinking events, moderate (>0.05 g/dL) and high level (>0.08 g/dL) of transdermal alcohol concentration, and estimated blood alcohol concentration drinking events were analyzed with Spearman's rank correlation test for validity comparisons.
No significant correlations were found between hair ethyl glucuronide values and total number, and moderate or high levels of detected drinking events by estimated blood alcohol concentration or transdermal alcohol concentration. Total number of drinking events detected and number of drinking events >0.08 g/dL using estimated blood alcohol concentration and transdermal alcohol concentration methods were significantly correlated with each other (respectively, R = .33, P < .05; R = .42, P < .05).
Our findings indicate that, due to the number of false negatives, hair ethyl glucuronide concentrations should be used with caution for monitoring abstinence from alcohol use.
本研究旨在评估毛发乙基葡萄糖醛酸浓度与皮肤酒精浓度和自我报告饮酒量的有效性。
本试验纳入了 25 名年龄在 16-24 岁之间的青少年和年轻成年女性，她们在基线前两周内报告了至少一次重度饮酒事件（≥4 杯）。所有参与者均被要求在为期一个月的前瞻性研究中佩戴酒精生物传感器。每周详细评估饮酒行为的自我报告。使用国家公路和运输安全管理局方程，根据自我报告数据估算血液酒精浓度。将皮肤酒精浓度和估计的血液酒精浓度数据分为高危（>0.05 g/dL 酒精）和高风险（>0.08 g/dL 酒精）饮酒事件。使用 Spearman 等级相关检验对毛发乙基葡萄糖醛酸浓度、总饮酒事件数、中值（>0.05 g/dL）和高值（>0.08 g/dL）皮肤酒精浓度以及估计的血液酒精浓度饮酒事件进行有效性比较。
毛发乙基葡萄糖醛酸值与通过估计的血液酒精浓度或皮肤酒精浓度检测到的总饮酒事件数以及中值或高值饮酒事件之间无显著相关性。通过估计的血液酒精浓度和皮肤酒精浓度检测到的总饮酒事件数和>0.08 g/dL 的饮酒事件数之间存在显著相关性（分别为 R =.33，P <.05；R =.42，P <.05）。
我们的研究结果表明，由于假阴性率较高，毛发乙基葡萄糖醛酸浓度的使用应谨慎，仅作为监测酒精使用的辅助手段。
