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头发中的乙基葡萄糖醛酸苷——监测酒精摄入的高效检测手段。

Ethyl glucuronide in hair - A highly effective test for the monitoring of alcohol consumption.

机构信息

Labor Krone, Siemensstr. 40, 32105, Bad Salzuflen, Germany.

出版信息

Forensic Sci Int. 2012 May 10;218(1-3):10-4. doi: 10.1016/j.forsciint.2011.10.007. Epub 2011 Oct 22.

DOI:10.1016/j.forsciint.2011.10.007
PMID:22019393
Abstract

In Germany drink driving offenders lose their license and must prove abstinence for one year in order to regain it. In this paper we assess the newly introduced ethyl glucuronide (EtG) tests in urine and hair in this alcohol abstinence monitoring. 20% (80 out of 386) of the 3cm long hair samples were tested positive for EtG in hair, compared to only 2% (92 out of 4248 samples) in urine in the same time period. Additionally 50% of the samples positive for EtG in hair had EtG values greater than 30pg/mg hair, indicating chronic alcohol consumption in the last three months. This study shows that four EtG tests in 3cm hair lengths reveal a significantly higher percentage of drink driving offenders who fail to be sober in the rehabilitation period, than do six random EtG tests in urine. Presumably, the hair test is more adequate to monitor long term alcohol abstinence than the urine test as defined by the new driving license re-granting medical and psychological assessment (MPA) in Germany.

摘要

在德国,酒后驾车者会被吊销驾照,并必须证明在一年内戒除酒瘾才能重新获得驾照。在本文中,我们评估了新引入的尿液和头发中乙基葡萄糖醛酸苷(EtG)测试在这种戒酒监测中的应用。在同一时期,386 个 3 厘米长的头发样本中,有 20%(80 个)的样本在头发中检测出 EtG 呈阳性,而在尿液中只有 2%(4248 个样本中的 92 个)呈阳性。此外,头发中 EtG 呈阳性的样本中有 50%的 EtG 值大于 30pg/mg 头发,表明在过去三个月中有慢性酒精摄入。这项研究表明,在康复期间,与 6 次随机尿液 EtG 检测相比,4 次头发 EtG 检测能显著提高未能戒酒的酒后驾车者的比例。据推测,与德国新的驾照重新发放医学和心理评估(MPA)规定的尿液检测相比,头发检测更能监测长期戒酒情况。

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Forensic Sci Int. 2012 May 10;218(1-3):10-4. doi: 10.1016/j.forsciint.2011.10.007. Epub 2011 Oct 22.
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引用本文的文献

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Biomolecules and Biomarkers Used in Diagnosis of Alcohol Drinking and in Monitoring Therapeutic Interventions.用于酒精饮用诊断及治疗干预监测的生物分子和生物标志物。
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Determination of ethyl glucuronide in hair: a rapid sample pretreatment involving simultaneous milling and extraction.毛发中乙基葡萄糖醛酸苷的测定:一种涉及同时研磨和提取的快速样品预处理方法。
Int J Legal Med. 2014 Jan;128(1):69-72. doi: 10.1007/s00414-013-0939-z. Epub 2013 Nov 13.
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