Veterans Affairs Capital Network (VISN 5) Mental Illness Research, Education, and Clinical Center, Baltimore, Maryland, USA.
Schizophr Res. 2012 Apr;136(1-3):51-4. doi: 10.1016/j.schres.2012.01.030. Epub 2012 Feb 13.
To examine the structural integrity of the dorsolateral prefrontal-basal ganglia-thalamocortical circuit in people with the deficit form of schizophrenia.
A three-dimensional structural MRI sequence was used to conduct morphometric assessments of cortical and subcortical regions in deficit and nondeficit outpatients with schizophrenia and healthy controls.
The superior prefrontal and superior and middle temporal gyral gray matter volumes were significantly smaller in the deficit versus the nondeficit group and normal control groups. There were no significant group differences in examined subcortical structures.
People with deficit schizophrenia are characterized by selective reductions in the prefrontal and temporal cortex.
研究缺陷型精神分裂症患者背外侧前额叶-基底神经节-丘脑皮质回路的结构完整性。
使用三维结构 MRI 序列对缺陷型和非缺陷型精神分裂症门诊患者及健康对照组的皮质和皮质下区域进行形态计量评估。
与非缺陷组和正常对照组相比，缺陷组患者的额上回和额中回、颞上回和颞中回的灰质体积明显更小。在被检查的皮质下结构中，各组间无显著差异。
缺陷型精神分裂症患者的前额叶和颞叶皮质存在选择性减少。
