核膜环境及其与癌症的联系。
The nuclear envelope environment and its cancer connections.
机构信息
Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA.
出版信息
Nat Rev Cancer. 2012 Feb 16;12(3):196-209. doi: 10.1038/nrc3219.
Abstract
Because of the association between aberrant nuclear structure and tumour grade, nuclear morphology is an indispensible criterion in the current pathological assessment of cancer. Components of the nuclear envelope environment have central roles in many aspects of cell function that affect tumour development and progression. As the roles of the nuclear envelope components, including nuclear pore complexes and nuclear lamina, are being deciphered in molecular detail there are opportunities to harness this knowledge for cancer therapeutics and biomarker development. In this Review, we summarize the progress that has been made in our understanding of the nuclear envelope and the implications of changes in this environment for cancer biology.
摘要
由于异常核结构与肿瘤分级之间存在关联，因此核形态学是当前癌症病理评估中不可或缺的标准。核包膜环境的组成部分在影响肿瘤发生和发展的细胞功能的许多方面发挥着核心作用。随着核包膜成分（包括核孔复合体和核纤层）的作用在分子细节方面被逐步揭示，我们有机会利用这些知识来开发癌症治疗药物和生物标志物。在这篇综述中，我们总结了在核包膜方面的认识进展，以及这种环境变化对癌症生物学的影响。
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