位点特异性烷基化寡脱氧核苷酸：用于诱变、DNA修复及DNA损伤结构效应的探针。 - Suppr

Site-specifically alkylated oligodeoxynucleotides: probes for mutagenesis, DNA repair and the structural effects of DNA damage.

作者信息

Basu A K, Essigmann J M

机构信息

Department of Chemistry, Whitaker College of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139.

出版信息

Mutat Res. 1990 Nov-Dec;233(1-2):189-201. doi: 10.1016/0027-5107(90)90162-w.

DOI:10.1016/0027-5107(90)90162-w

PMID:2233800

Abstract

摘要

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Site-specifically alkylated oligodeoxynucleotides: probes for mutagenesis, DNA repair and the structural effects of DNA damage.位点特异性烷基化寡脱氧核苷酸：用于诱变、DNA修复及DNA损伤结构效应的探针。

Mutat Res. 1990 Nov-Dec;233(1-2):189-201. doi: 10.1016/0027-5107(90)90162-w.

Site-specifically modified oligodeoxynucleotides as probes for the structural and biological effects of DNA-damaging agents.

Chem Res Toxicol. 1988 Jan-Feb;1(1):1-18. doi: 10.1021/tx00001a001.

Repair of triplex-directed DNA alkylation by nucleotide excision repair.通过核苷酸切除修复对三链定向DNA烷基化进行修复。

Nucleic Acids Res. 2001 Nov 1;29(21):4257-63. doi: 10.1093/nar/29.21.4257.

Overexpression of endonuclease III protects Escherichia coli mutants defective in alkylation repair against lethal effects of methylmethanesulphonate.核酸内切酶III的过表达可保护在烷基化修复方面存在缺陷的大肠杆菌突变体免受甲磺酸甲酯的致死效应。

FEBS Lett. 2001 Feb 23;491(1-2):59-62. doi: 10.1016/s0014-5793(01)02156-1.

Structural insight into repair of alkylated DNA by a new superfamily of DNA glycosylases comprising HEAT-like repeats.对由包含类热重复序列的新型DNA糖基化酶超家族修复烷基化DNA的结构洞察。

Nucleic Acids Res. 2007;35(7):2451-9. doi: 10.1093/nar/gkm039. Epub 2007 Mar 29.

A novel method for site specific introduction of single model oxidative DNA lesions into oligodeoxyribonucleotides.一种将单一模式氧化性DNA损伤位点特异性引入寡脱氧核糖核苷酸的新方法。

Nucleic Acids Res. 1993 Apr 11;21(7):1563-8. doi: 10.1093/nar/21.7.1563.

Oligonucleotide-directed site-specific mutagenesis in Drosophila melanogaster.

Proc Natl Acad Sci U S A. 1992 Mar 1;89(5):1735-9. doi: 10.1073/pnas.89.5.1735.

Structural basis for enzymatic excision of N1-methyladenine and N3-methylcytosine from DNA.从DNA中酶促切除N1-甲基腺嘌呤和N3-甲基胞嘧啶的结构基础。

EMBO J. 2007 Apr 18;26(8):2206-17. doi: 10.1038/sj.emboj.7601662. Epub 2007 Mar 29.

Gene targeted DNA double-strand break induction by (125)I-labeled triplex-forming oligonucleotides is highly mutagenic following repair in human cells.（125）I标记的三链形成寡核苷酸诱导的基因靶向DNA双链断裂在人类细胞修复后具有高度致突变性。

Nucleic Acids Res. 1999 Nov 1;27(21):4282-90. doi: 10.1093/nar/27.21.4282.

Mutation spectra of M13 vectors containing site-specific Cis-Syn, Trans-Syn-I, (6-4), and Dewar pyrimidone photoproducts of thymidylyl-(3'-->5')-thymidine in Escherichia coli under SOS conditions.在大肠杆菌处于SOS条件下时，含有胸苷酰-（3'→5'）-胸苷的位点特异性顺式-环丁烷嘧啶二聚体、反式-环丁烷嘧啶二聚体-I、（6-4）光产物和杜瓦嘧啶酮光产物的M13载体的突变谱。

Biochemistry. 1996 Apr 2;35(13):4146-54. doi: 10.1021/bi951975c.

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DNA Damage, Mutagenesis and Cancer.DNA 损伤、突变与癌症。

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Impact of bistrand abasic sites and proximate orientation on DNA global structure and duplex energetics.双链无碱基位点及相邻取向对DNA整体结构和双链体能量学的影响。

Biopolymers. 2018 Aug;109(8):e23098. doi: 10.1002/bip.23098. Epub 2018 Jan 11.

Translesion Synthesis of 2'-Deoxyguanosine Lesions by Eukaryotic DNA Polymerases.真核生物DNA聚合酶对2'-脱氧鸟苷损伤的跨损伤合成

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Synthesis of Mitomycin C and Decarbamoylmitomycin C N(2) deoxyguanosine-adducts.丝裂霉素C和去氨甲酰基丝裂霉素C N(2)-脱氧鸟苷加合物的合成。

Bioorg Chem. 2016 Apr;65:90-9. doi: 10.1016/j.bioorg.2016.02.003. Epub 2016 Feb 11.

Mutagenic spectra arising from replication bypass of the 2,6-diamino-4-hydroxy-N(5)-methyl formamidopyrimidine adduct in primate cells.灵长类细胞中2,6-二氨基-4-羟基-N(5)-甲基甲酰胺嘧啶加合物复制绕过产生的诱变谱。

Chem Res Toxicol. 2013 Jul 15;26(7):1108-14. doi: 10.1021/tx4001495. Epub 2013 Jun 13.

Replication of the 2,6-diamino-4-hydroxy-N(5)-(methyl)-formamidopyrimidine (MeFapy-dGuo) adduct by eukaryotic DNA polymerases.真核 DNA 聚合酶对 2,6-二氨基-4-羟基-N(5)-(甲基)-甲酰胺基嘧啶(MeFapy-dGuo)加合物的复制。

Chem Res Toxicol. 2012 Aug 20;25(8):1652-61. doi: 10.1021/tx300113e. Epub 2012 Jul 6.

Repair of O4-alkylthymine by O6-alkylguanine-DNA alkyltransferases.O6-烷基鸟嘌呤-DNA 烷基转移酶修复 O4-烷基胸腺嘧啶。

J Biol Chem. 2010 Mar 12;285(11):8185-95. doi: 10.1074/jbc.M109.045518. Epub 2009 Dec 21.

Cytosine methylation effects on the repair of O6-methylguanines within CG dinucleotides.胞嘧啶甲基化对CG二核苷酸内O6-甲基鸟嘌呤修复的影响。

J Biol Chem. 2009 Aug 21;284(34):22601-10. doi: 10.1074/jbc.M109.000919. Epub 2009 Jun 15.

Synthesis of an oligodeoxyribonucleotide adduct of mitomycin C by the postoligomerization method via a triamino mitosene.通过三氨基丝裂霉素经由寡聚后方法合成丝裂霉素C的寡脱氧核糖核苷酸加合物。

J Am Chem Soc. 2008 Jul 23;130(29):9556-65. doi: 10.1021/ja802118p. Epub 2008 Jun 28.

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Site-specifically alkylated oligodeoxynucleotides: probes for mutagenesis, DNA repair and the structural effects of DNA damage.

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