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Evaluation of the mutagenic potential of endosulfan using the Salmonella/mammalian microsome assay.

作者信息

Pandey N, Gundevia F, Ray P K

机构信息

Environmental Microbiology Section, Industrial Toxicology Research Centre, Lucknow, India.

出版信息

Mutat Res. 1990 Oct;242(2):121-5. doi: 10.1016/0165-1218(90)90037-3.

DOI:10.1016/0165-1218(90)90037-3
PMID:2233828
Abstract

The mutagenic potential of endosulfan, a polychlorinated insecticide, was assessed using the highly sensitive Salmonella tester strains TA97(a), TA98, TA100 and TA102. It exhibited a toxic effect at dose levels of 50 micrograms/plate and higher. Plate incorporation studies did not show mutagenic response with any of the tester strains used. A modification of the assay using a preincubation procedure showed mutagenic activity with and without metabolic activation with TA97(a) only. Increased toxicity was observed after addition of phenobarbital-induced S9 mix.

摘要

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