在使用新型测试菌株的沙门氏菌/微粒体试验中，丁基羟基茴香醚、丁基羟基甲苯和叔丁基对苯二酚不具有致突变性。

Butylated hydroxyanisole, butylated hydroxytoluene and tert.-butylhydroquinone are not mutagenic in the Salmonella/microsome assay using new tester strains.

作者信息

Hageman G J, Verhagen H, Kleinjans J C

机构信息

Department of Human Biology, State University of Limburg, Maastricht, The Netherlands.

出版信息

Mutat Res. 1988 Jul;208(3-4):207-11. doi: 10.1016/0165-7992(88)90062-0.

DOI:10.1016/0165-7992(88)90062-0

PMID:3041273

Abstract

The phenolic antioxidants butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) and tert.-butylhydroquinone (TBHQ) were reassessed for mutagenic activity using the recently developed Salmonella tester strains TA97, TA102 and TA104, and in addition TA100. None of the phenolic antioxidants showed mutagenic activity, either with or without metabolic activation. At doses of 100 micrograms/plate and higher all 3 phenolic antioxidants exhibited toxic effects. A modification of the assay using the preincubation procedure with strain TA104 did not affect mutation frequencies. Combinations of BHA and BHT, tested to detect possible synergistic effects, did not exert mutagenic activity.

摘要

使用最近开发的沙门氏菌测试菌株TA97、TA102、TA104以及另外的TA100，对酚类抗氧化剂丁基羟基茴香醚（BHA）、丁基羟基甲苯（BHT）和叔丁基对苯二酚（TBHQ）的致突变活性进行了重新评估。无论有无代谢活化，这些酚类抗氧化剂均未显示出致突变活性。在每平皿100微克及更高剂量下，所有3种酚类抗氧化剂均表现出毒性作用。使用TA104菌株的预孵育程序对该试验进行的修改并未影响突变频率。为检测可能的协同效应而测试的BHA和BHT组合未产生致突变活性。