伯氨喹、戊喹和扑疟喹在沙门氏菌/哺乳动物微粒体试验中的致突变性评估。

Mutagenic evaluation of primaquine, pentaquine and pamaquine in the Salmonella/mammalian microsome assay.

作者信息

Ono T, Norimatsu M, Yoshimura H

机构信息

National Veterinary Assay Laboratory, Tokyo, Japan.

出版信息

Mutat Res. 1994 Sep;325(1):7-10. doi: 10.1016/0165-7992(94)90021-3.

DOI:10.1016/0165-7992(94)90021-3

PMID:7521013

Abstract

The 8-aminoquinolines, primaquine, pentaquine and pamaquine, were investigated for mutagenic activity in Salmonella typhimurium strains TA100, TA98, TA97 and TA102 in the rat liver microsomal activation system. Primaquine and pentaquine induced mutations in TA97 in the presence and absence of S9 mix. Pamaquine was mutagenic to TA98 only in the absence of S9 mix.

摘要

研究了8-氨基喹啉类药物伯氨喹、戊喹和扑疟喹在大鼠肝微粒体激活系统中对鼠伤寒沙门氏菌TA100、TA98、TA97和TA102菌株的致突变活性。在有和没有S9混合物存在的情况下，伯氨喹和戊喹在TA97中诱导了突变。扑疟喹仅在没有S9混合物时对TA98具有致突变性。