体内接触抗肿瘤药物对人淋巴细胞DNA修复和复制的影响。
Effects of in vivo exposure to antineoplastic drugs on DNA repair and replication in human lymphocytes.
作者信息
Celotti L, Biasin R, Ferraro P, Fiorentino M
机构信息
Department of Biology, University of Padua, Italy.
出版信息
Mutat Res. 1990 Nov;245(3):217-22. doi: 10.1016/0165-7992(90)90053-m.
PMID:2233843
Abstract
In peripheral blood lymphocytes of 12 nurses and 3 patients exposed to antineoplastic drugs we determined the ability to repair DNA after UV irradiation and DNA replicative synthesis after stimulation by PHA. In nurses the levels of unscheduled DNA synthesis and DNA replication were not different than in a control group, whereas in patients significant changes were observed during and after chemotherapy in the level of both types of DNA synthesis.
摘要
在12名护士和3名接触抗肿瘤药物的患者的外周血淋巴细胞中，我们测定了紫外线照射后修复DNA的能力以及在PHA刺激后的DNA复制合成能力。护士组中DNA的非预定合成水平和DNA复制水平与对照组并无差异，而在患者中，化疗期间及化疗后两种类型的DNA合成水平均出现了显著变化。
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