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新生霉素；一种对哺乳动物细胞中紫外线诱导的损伤而非X射线诱导的损伤具有修复抑制作用的物质。

Novobiocin; an inhibitor of the repair of UV-induced but not X-ray-induced damage in mammalian cells.

作者信息

Collins A, Johnson R

出版信息

Nucleic Acids Res. 1979 Nov 10;7(5):1311-20. doi: 10.1093/nar/7.5.1311.

DOI:10.1093/nar/7.5.1311
PMID:514814
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC342304/
Abstract

In addition to inhibiting replicative DNA synthesis in HeLa cells, novobiocin has a severe effect on the cellular response to UV irradiation, reducing the number of breaks made in pre-existing DNA by the excision repair process. The inhibition of UV repair by novobiocin is reflected in enhanced UV-killing of these cells. Rejoining of DNA after X irradiation is not impaired by novobiocin. The recognition and removal of UV damage may require unwinding of the DNA by gyrase, which--in bacteria--is the target for novobiocin.

摘要

除了抑制HeLa细胞中的复制性DNA合成外，新生霉素对细胞对紫外线照射的反应有严重影响，减少了切除修复过程中在已有DNA上产生的断裂数量。新生霉素对紫外线修复的抑制作用表现为这些细胞的紫外线杀伤增强。X射线照射后DNA的重新连接不受新生霉素的影响。紫外线损伤的识别和去除可能需要由促旋酶解开DNA，而在细菌中，促旋酶是新生霉素的作用靶点。

相似文献

1
Novobiocin; an inhibitor of the repair of UV-induced but not X-ray-induced damage in mammalian cells.新生霉素；一种对哺乳动物细胞中紫外线诱导的损伤而非X射线诱导的损伤具有修复抑制作用的物质。
Nucleic Acids Res. 1979 Nov 10;7(5):1311-20. doi: 10.1093/nar/7.5.1311.
2
Comparison of effects of fostriecin, novobiocin, and camptothecin, inhibitors of DNA topoisomerases, on DNA replication and repair in human cells.DNA拓扑异构酶抑制剂福司曲星、新生霉素和喜树碱对人细胞DNA复制和修复影响的比较
Nucleic Acids Res. 1990 Feb 25;18(4):1007-13. doi: 10.1093/nar/18.4.1007.
3
Inhibitors of repair DNA synthesis.DNA修复合成抑制剂。
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4
Studies on the inhibition of repair of ultraviolet- and methyl methanesulfonate-induced damage in the DNA of human fibroblasts by novobiocin.新生霉素对人成纤维细胞DNA中紫外线和甲磺酸甲酯诱导损伤修复的抑制作用研究
Nucleic Acids Res. 1982 Oct 11;10(19):6207-19. doi: 10.1093/nar/10.19.6207.
5
Effects of DNA replication inhibitors on UV excision repair in synchronised human cells.DNA复制抑制剂对同步化人类细胞紫外线切除修复的影响。
Nucleic Acids Res. 1982 Sep 11;10(17):5357-68. doi: 10.1093/nar/10.17.5357.
6
Specificity and completeness of inhibition of DNA repair by novobiocin and aphidicolin.新生霉素和阿非迪霉素对DNA修复抑制作用的特异性和完整性
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Effect of 3-aminobenzamide on the process of ultraviolet-induced DNA excision repair.3-氨基苯甲酰胺对紫外线诱导的DNA切除修复过程的影响。
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8
Direct inhibition of u.v.-induced DNA excision repair in human cells by novobiocin, coumermycin and nalidixic acid.新生霉素、香豆霉素和萘啶酸对人细胞中紫外线诱导的DNA切除修复的直接抑制作用。
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The inhibition of repair in UV irradiated human cells.紫外线照射的人类细胞中修复的抑制作用。
Mutat Res. 1977 Mar;42(3):413-32. doi: 10.1016/s0027-5107(77)80046-8.

引用本文的文献

1
Novobiocin Inhibits the Antimicrobial Resistance Acquired through DNA Damage-Induced Mutagenesis in Acinetobacter baumannii.新生霉素可抑制鲍曼不动杆菌因DNA损伤诱导的诱变而获得的抗菌耐药性。
Antimicrob Agents Chemother. 2015 Oct 26;60(1):637-9. doi: 10.1128/AAC.01810-15. Print 2016 Jan.
2
Effects of novobiocin on adenovirus DNA synthesis and encapsidation.新生霉素对腺病毒DNA合成和衣壳化的影响。
Nucleic Acids Res. 1980 Apr 11;8(7):1625-41. doi: 10.1093/nar/8.7.1625.
3
Studies on the inhibition of repair of ultraviolet- and methyl methanesulfonate-induced damage in the DNA of human fibroblasts by novobiocin.新生霉素对人成纤维细胞DNA中紫外线和甲磺酸甲酯诱导损伤修复的抑制作用研究
Nucleic Acids Res. 1982 Oct 11;10(19):6207-19. doi: 10.1093/nar/10.19.6207.
4
Inhibitors of repair DNA synthesis.DNA修复合成抑制剂。
Nucleic Acids Res. 1982 Feb 25;10(4):1203-13. doi: 10.1093/nar/10.4.1203.
5
Assimilation of single-stranded donor deoxyribonucleic acid fragments by nucleoids of competent cultures of Bacillus subtilis.枯草芽孢杆菌感受态培养物的类核对单链供体脱氧核糖核酸片段的同化作用。
J Bacteriol. 1981 Mar;145(3):1177-88. doi: 10.1128/jb.145.3.1177-1188.1981.
6
Fanconi's anemia: anomaly of enzyme passage through the nuclear membrane? Anomalous intracellular distribution of topoisomerase activity in placental extracts in a case of Fanconi's anemia.范科尼贫血：酶通过核膜的异常现象？一例范科尼贫血病例中胎盘提取物拓扑异构酶活性的细胞内异常分布。
Hum Genet. 1981;58(2):149-55. doi: 10.1007/BF00278700.
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Inhibition of recovery from potentially lethal damage by chemicals in Chinese hamster V79 A cells.
Radiat Environ Biophys. 1985;24(2):89-98. doi: 10.1007/BF01229814.
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Symposium on "Genetics and regulation of DNA repair", November 24, 1984, London. Abstracts.“DNA修复的遗传学与调控”研讨会，1984年11月24日，伦敦。摘要
Br J Cancer. 1985 Apr;51(4):603-10. doi: 10.1038/bjc.1985.83.
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Stimulation of DNA repair synthesis of rat thymocytes by novobiocin and nalidixic acid in vitro without detectable DNA damage.新生霉素和萘啶酸在体外刺激大鼠胸腺细胞的DNA修复合成，而未检测到DNA损伤。
Arch Toxicol. 1987 Jun;60(4):287-92. doi: 10.1007/BF01234667.
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Induction of urokinase-type plasminogen activator by UV light in human fetal fibroblasts is mediated through a UV-induced secreted protein.紫外线诱导人胎儿成纤维细胞产生尿激酶型纤溶酶原激活剂是通过紫外线诱导分泌的一种蛋白质介导的。
Mol Cell Biol. 1987 Feb;7(2):622-31. doi: 10.1128/mcb.7.2.622-631.1987.

本文引用的文献

1
Letter: Radiation-induced single-strand breaks in DNA determined by rate of alkaline strand separation and hydroxylapatite chromatography: an alternative to velocity sedimentation.
Int J Radiat Biol Relat Stud Phys Chem Med. 1974 Nov;26(5):493-7. doi: 10.1080/09553007414551511.
2
Two forms of repair in the DNA of human cells damaged by chemical carcinogens and mutagens.人类细胞中被化学致癌物和诱变剂损伤的DNA的两种修复形式。
Cancer Res. 1974 Dec;34(12):3318-25.
3
DNA damage in ultraviolet-irradiated HeLa and CHO-Kl cells examined by alkaline lysis and hydroxyapatite chromatography.通过碱性裂解和羟基磷灰石层析法检测紫外线照射的HeLa细胞和CHO-K1细胞中的DNA损伤。
Biochim Biophys Acta. 1977 Oct 18;478(4):461-73. doi: 10.1016/0005-2787(77)90101-0.
4
The inhibition of repair in UV irradiated human cells.紫外线照射的人类细胞中修复的抑制作用。
Mutat Res. 1977 Mar;42(3):413-32. doi: 10.1016/s0027-5107(77)80046-8.
5
Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase.新生霉素和香豆霉素抑制由DNA促旋酶催化的DNA超螺旋化。
Proc Natl Acad Sci U S A. 1976 Dec;73(12):4474-8. doi: 10.1073/pnas.73.12.4474.
6
Coumermycin A1: A preferential inhibitor of replicative DNA synthesis in Escherichia coli. I. In vivo characterization.香豆霉素A1：大肠杆菌中复制性DNA合成的优先抑制剂。I. 体内特性
Biochemistry. 1976 Aug 24;15(17):3769-77. doi: 10.1021/bi00662a020.
7
The influence of inhibitors on dimer removal and repair of single-strand breaks in normal and bromodeoxyuridine substituted DNA of HeLa cells.抑制剂对HeLa细胞正常DNA和溴脱氧尿苷取代DNA中二聚体去除及单链断裂修复的影响。
Biochim Biophys Acta. 1978 Nov 21;521(1):134-43. doi: 10.1016/0005-2787(78)90256-3.
8
Reversal of the changes in DNA and chromosome structure which follow the inhibition of UV-induced repair in human cells.人类细胞中紫外线诱导修复受到抑制后，DNA和染色体结构变化的逆转。
Biochem Biophys Res Commun. 1978 Jan 30;80(2):361-9. doi: 10.1016/0006-291x(78)90685-x.
9
The effect of cytosine arabinoside on the frequency of single-strand breaks in DNA of mammalian cells following irradiation or chemical treatment.阿糖胞苷对经辐射或化学处理的哺乳动物细胞DNA中单链断裂频率的影响。
Biochim Biophys Acta. 1977 Sep 6;478(1):1-8. doi: 10.1016/0005-2787(77)90238-6.
10
Repair and survival after UV in quiescent and proliferating Microtus agrestis cells: different rates of incision and different dependence on DNA precursor supply.静止和增殖的田鼠细胞经紫外线照射后的修复与存活：不同的切口速率以及对DNA前体供应的不同依赖性。
J Cell Physiol. 1979 Apr;99(1):125-37. doi: 10.1002/jcp.1040990114.