新生霉素；一种对哺乳动物细胞中紫外线诱导的损伤而非X射线诱导的损伤具有修复抑制作用的物质。
Novobiocin; an inhibitor of the repair of UV-induced but not X-ray-induced damage in mammalian cells.
作者信息
Collins A, Johnson R
出版信息
Nucleic Acids Res. 1979 Nov 10;7(5):1311-20. doi: 10.1093/nar/7.5.1311.
Abstract
In addition to inhibiting replicative DNA synthesis in HeLa cells, novobiocin has a severe effect on the cellular response to UV irradiation, reducing the number of breaks made in pre-existing DNA by the excision repair process. The inhibition of UV repair by novobiocin is reflected in enhanced UV-killing of these cells. Rejoining of DNA after X irradiation is not impaired by novobiocin. The recognition and removal of UV damage may require unwinding of the DNA by gyrase, which--in bacteria--is the target for novobiocin.
摘要
除了抑制HeLa细胞中的复制性DNA合成外，新生霉素对细胞对紫外线照射的反应有严重影响，减少了切除修复过程中在已有DNA上产生的断裂数量。新生霉素对紫外线修复的抑制作用表现为这些细胞的紫外线杀伤增强。X射线照射后DNA的重新连接不受新生霉素的影响。紫外线损伤的识别和去除可能需要由促旋酶解开DNA，而在细菌中，促旋酶是新生霉素的作用靶点。
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本文引用的文献
1
Letter: Radiation-induced single-strand breaks in DNA determined by rate of alkaline strand separation and hydroxylapatite chromatography: an alternative to velocity sedimentation.
Int J Radiat Biol Relat Stud Phys Chem Med. 1974 Nov;26(5):493-7. doi: 10.1080/09553007414551511.
2
Two forms of repair in the DNA of human cells damaged by chemical carcinogens and mutagens.人类细胞中被化学致癌物和诱变剂损伤的DNA的两种修复形式。
Cancer Res. 1974 Dec;34(12):3318-25.
3
DNA damage in ultraviolet-irradiated HeLa and CHO-Kl cells examined by alkaline lysis and hydroxyapatite chromatography.通过碱性裂解和羟基磷灰石层析法检测紫外线照射的HeLa细胞和CHO-K1细胞中的DNA损伤。
Biochim Biophys Acta. 1977 Oct 18;478(4):461-73. doi: 10.1016/0005-2787(77)90101-0.
4
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6
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Biochemistry. 1976 Aug 24;15(17):3769-77. doi: 10.1021/bi00662a020.
7
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8
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10
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