甲状腺功能减退性肌病的中枢性改变：一例报告
Central changes in hypothyroid myopathy: a case report.
作者信息
Evans R M, Watanabe I, Singer P A
机构信息
Neurology Service, Veterans Administration Medical Center, Kansas City, MO 64128.
出版信息
Muscle Nerve. 1990 Oct;13(10):952-6. doi: 10.1002/mus.880131011.
A muscle biopsy from a patient with hypothyroid myopathy showed striking central changes. "Cores" were seen in most type 1 fibers with oxidative enzyme preparations. Electron microscopy of these areas revealed Z disc streaming, myofilament disruption, and absent mitochondria. The myopathy rapidly improved with thyroxine treatment. This biopsy is of interest, as numerous "cores" have not previously been reported in hypothyroid myopathy.
一名甲状腺功能减退性肌病患者的肌肉活检显示出明显的中央改变。在大多数1型纤维的氧化酶制剂中可见“核心”。这些区域的电子显微镜检查显示Z盘流、肌丝破坏和线粒体缺失。甲状腺素治疗后，肌病迅速改善。该活检结果令人感兴趣，因为此前甲状腺功能减退性肌病中尚未有大量“核心”的报道。
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