Division of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy.
Eur J Immunol. 2020 Mar;50(3):317-325. doi: 10.1002/eji.201848054. Epub 2020 Feb 6.
Humans are constantly exposed to fungi, either in the form of commensals at epithelial barriers or as inhaled spores. Innate immune cells play a pivotal role in maintaining commensal relationships and preventing skin, mucosal, or systemic fungal infections due to the expression of pattern recognition receptors that recognize fungal cell wall components and modulate both their activation status and the ensuing adaptive immune response. Commensal fungi also play a critical role in the modulation of homeostasis and disease susceptibility at epithelial barriers. This review will outline cellular and molecular mechanisms of anti-fungal innate immunity focusing on C-type lectin receptors and their relevance in the context of host-fungi interactions at skin and mucosal surfaces in murine experimental models as well as patients susceptible to fungal infections.
人类不断地接触真菌，无论是以表皮屏障共生体的形式，还是以吸入孢子的形式。由于先天免疫细胞表达模式识别受体，识别真菌细胞壁成分，并调节其激活状态和随后的适应性免疫反应，因此在维持共生关系和预防皮肤、黏膜或系统性真菌感染方面发挥着关键作用。共生真菌在调节上皮屏障的体内平衡和疾病易感性方面也起着至关重要的作用。这篇综述将概述抗真菌先天免疫的细胞和分子机制，重点介绍 C 型凝集素受体及其在皮肤和黏膜表面宿主-真菌相互作用的小鼠实验模型以及易感染真菌的患者中的相关性。
